Background: The purpose of the present study is to investigate the effect of one session of exhaustive activity with supplementation of beta-alanine on the level of carnosine and muscle strength of upper and lower extremities of bodybuilding athletes. Materials and Methods: Twenty bodybuilders were randomly divided into two equal groups of 10 who were taking supplemental beta-alanine and placebo. The experimental group consumed beta-alanine for 21 days and the placebo group received dextrose. The level of carnosine and muscle strength of the upper and lower extremities were measured before and after supplementation. Blood sampling was done before and after supplementation after session of exhaustive workout. Paired t-test and ANCOVA were used for data analysis using SPSS 21 software at a significant level (p <0.05). Results: The results of paired t-test showed that in all three variables of lactate, carnosine and growth hormone only in the beta-alanine group, a significant change was observed between pre-test and post-test (P <0.05). And amount of these variables in the post-test showed a significant difference compared to the pre-test. Also, ANCOVA test results indicated that there was a significant difference between the two groups of beta-alanine and placebo in all three variables (P <0.05). Conclusion: Beta-alanine supplementation with an exhaustive exercise session increases the level of carnosine in blood and hence increases the fatigue tolerance of bodybuilding athletes and ultimately improves the muscle strength of the upper and lower extremities of athletes and bodybuilders. Therefore, bodybuilders can use this supplement to improve their performance. Manuscript profile

Background: Metabolic syndrome includes a set of metabolic disorders that expose the patient to cardiovascular disease and diabetes. The aim of the present study was to evaluate the effect of High intensity interval training and Eryngium billardieri extract consumption on the expression of visceral fat matrix metalloproteinase-2 gene and insulin resistance in rats with metabolic syndrome. Methods: In this experimental study, 32 male Sprague-Dawley rats weighing 200-250 g were randomly divided into 4 groups: 1- Healthy group 2- Metabolic syndrome 3- Metabolic syndrome + Eryngium billardieri 4- Metabolic syndrome + Eryngium billardieri + HIIT. The training protocol was performed on a rodent treadmill for 8 weeks and 5 sessions per week and 125 mg of Eryngium billardieri extract per kilogram of body weight was given by gastric gavage 5 days a week for 8 weeks. At the end of the eighth week, sample of visceral adipose tissue was taken to examine the expression of MMP-2 gene. Animal blood was collected from the heart. ANOVA were used for data analysis using SPSS 23 software at a significant level (p <0.05). Tukey significance test was used to compare significant differences. Results: Eight weeks of intense intermittent exercise with consumption of Eryngium billardieri extract caused a significant decrease in MMP-2 gene levels and glucose and insulin levels in comparison with the metabolic syndrome group (P <0.05). Conclusion: According to the results of the study, it seems that High intensity interval training with the use of Eryngium billardieri extract helps to improve insulin resistance and reduce MMP2. Manuscript profile

Background: Fatty liver disease is also known as fatty liver syndrome and is also called hepatic steatosis the aim of this study was to evaluate the effect of eight weeks of aerobic exercise and probiotic intake on FOXA1 gene expression in rats with fatty liver. Methods: This study is an experimental laboratory study. Thirty-two male wistar rats were divided into 4 groups of 8 in the healthy, steatosis, steatosis + probiotic, steatosis + probiotic +aerobic exercise groups and tested for 8 weeks. The exercise protocol was as follows: in the first week from 10 minutes of running at a speed of 18 meters per minute to the eighth week with 60 minutes of running at a speed of 28 meters per minute. Consumption of probiotics; Relevant groups received 109 CFU / ml of Lactobacillus rhamnosus GG by gavage daily for 5 weeks and 5 days a week. RT-pcr method was used to evaluate the expression of FOXA1gene. ANOVA were used for data analysis using SPSS 23 software at a significant level (p <0.05). Results: The results showed that eight weeks of aerobic exercise with probiotic intake had a significant decrease on the expression of FOXA1 gene and LDL in rats with fatty liver (P <0.05). Conclusion: According to the results of the study, It seems that aerobic exercise with probiotics intake can improve the liver function of non-alcoholic fatty liver patients. Manuscript profile

Background: Resistance training improves skeletal muscle function by affecting the proteins of the nervous system. However, there are conflicting results regarding the effects of resistance training on Neural cell adhesion molecule (NCAM) gene expression. Therefore, the present study aimed to investigate the effect of 4 weeks of increasing resistance training on NCAM gene expression in the gastrocnemius muscle of healthy male rats. Materials and Methods: In an experimental trial, 12 young male rats were randomly divided into 2 groups of 6, including the control and resistance training groups. The training group performed increasing resistance training 5 days a week for 4 weeks on a special rodent ladder. Forty-eight hours after the end of the training intervention, the rats were sacrificed and the gastrocnemius muscle tissue was extracted for the expression of the NCAM gene using the real-time method. Results: resistance training in the neuromuscular junction, gastrocnemius muscle increased NCAM gene expression (P=0.036) compared to the control group. Conclusion: Four weeks of resistance training can improve skeletal muscle function by increasing NCAM gene expression at the end of muscle fibers. Manuscript profile