List of Articles Scaffold

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  1 - Application of stem cells and tissue engineering in wound management
  Saeed Farzad-Mohajeri Mahdi ghamsari
  Optimum healing of a cutaneous wound involves a cascade of biologic cellular and molecular processes. When the normal biological process fails for any reason, healing process can cease resulting in chronic wounds. In Addition, the body cannot repair some extensive wou More

  Optimum healing of a cutaneous wound involves a cascade of biologic cellular and molecular processes. When the normal biological process fails for any reason, healing process can cease resulting in chronic wounds. In Addition, the body cannot repair some extensive wounds without problem. These Issues surrounding wound healing as well as increased medical healthcare in this field, developed novel wound therapies. Regardless of the type of these specific advanced wound care methods, the ideal goal would be to regenerate tissues such that both the structural and functional properties of the wounded tissue are restored to the levels before injury. Tissue engineering and stem cells may be the solution. A range of cell based therapies and tissue engineered scaffolds have begun to cross the rift from bench to bedside. These therapies have been heralded as a promising means by which to surpass current limitations in wound management. The wide differentiation potential of stem cells allows for the possibility of regenerating lost or damaged skin, while their ability to immunomodulate the wound bed from afar suggests that their clinical applications need not be restricted to direct tissue formation. The data suggests that the appropriate application of stem cells and scaffolds can accelerate wound healing. The clinical utility of stem cells and tissue engineering has been demonstrated across dozens of clinical trials in wound therapy. Manuscript profile
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  2 - Nanoparticles for Tendon Healing and Regeneration
  sara javanmardi Dara Azizi
  Tendon tissue has limited regeneration potential and usually the consequent formation of scar tissue causes inferior mechanical properties. Nanoparticles could be used in different way to improve tendon healing and regeneration, ranging from scaffolds manufacturing (inc More

  Tendon tissue has limited regeneration potential and usually the consequent formation of scar tissue causes inferior mechanical properties. Nanoparticles could be used in different way to improve tendon healing and regeneration, ranging from scaffolds manufacturing (increasing the strength and endurance or anti-adhesions, anti-microbial, and ante inflammatory properties) to gene therapy. This paper aims to summarize the most relevant studies showing the potential application of nanoparticles for tendon tissue regeneration. Manuscript profile
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  3 - Designing and Validating Dynamic Computer-Based Scaffolding Model in Virtual In-Service Teacher Training
  Zeynab Rashidi mohammadreza nili Esmaeil  Zaraii Ali Delavar
  In virtual in-service teacher training, instructional support or scaffolding is an essential component of effective training that can be provided in the form of computer-based scaffolding. Personalization of computer-based scaffolding is achieved with dynamic computer-b More

  In virtual in-service teacher training, instructional support or scaffolding is an essential component of effective training that can be provided in the form of computer-based scaffolding. Personalization of computer-based scaffolding is achieved with dynamic computer-based scaffolding. The purpose of this study is to design and validate a model of dynamic computer-based scaffolding in virtual in-service teacher training. The research method used in this research was mixed method with sequential exploratory design. In qualitative research, the synthesis research method was used and the components of the model were extracted and a concept and process model was designed. Quantitative research was used to validate the model and survey research method and questionnaire were used and the internal validity of the proposed model was confirmed. Dynamic computer-based scaffolding model in virtual in-service teacher training has 8 main components and 47 sub-components. Key components include analysis with 11 subcomponents, design with 16 subcomponents, development with 3 subcomponents, implementation with 3 subcomponents, evaluation with 8 subcomponents, dissermination with 3 subcomponents, process evaluation and revision, and review and revision with 3 subcomponents. Internal validaty findings from experts showed that concept and process model have a high internal validity. Dynamic computer-based scaffolding model in online in-service teacher training can be used to design dynamic and computer-based instructional support and lead to learning and independent performance in the future. Manuscript profile
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  4 - A Review of Hydrogels Containing Fibers in Drug Delivery Systems
  Mohammad Hossein Karami Majid Abdouss Mohammadreza Kalaee Omid Moradi
  Hydrogels are three-dimensional networks of hydrophilic polymers capable of absorbing and retaining significant amounts of fluids, which are also widely applied in wound healing, cartilage tissue engineering, bone tissue engineering, release of proteins, growth factors, More

  Hydrogels are three-dimensional networks of hydrophilic polymers capable of absorbing and retaining significant amounts of fluids, which are also widely applied in wound healing, cartilage tissue engineering, bone tissue engineering, release of proteins, growth factors, and antibiotics. In the past decades, a lot of research has been done to accelerate wound healing. Hydrogel-based scaffolds have been a recurring solution in both cases, although their mechanical stability remains a challenge, some of which have already reached the market. To overcome this limitation, the reinforcement of hydrogels with fibers has been investigated. The structural similarity of hydrogel fiber composites to natural tissues has been a driving force for the optimization and exploration of these systems in biomedicine. Indeed, the combination of hydrogel formation techniques and fiber spinning methods has been very important in the development of scaffold systems with improved mechanical strength and medicinal properties. Hydrogel has the ability to absorb secretions and maintain moisture balance in the wound. In turn, the fibers follow the structure of the extracellular matrix (ECM). The combination of these two structures (fiber and hydrogel ) in a scaffold is expected to facilitate healing by creating a suitable environment by identifying and connecting cells with the moist and breathing space required for healthy tissue formation. Modifying the surface of fibers by physical and chemical methods improves the performance of hydrogel composites containing Manuscript profile
• Open Access Article
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  5 - A Review of Hydrogels Containing Fibers in Drug Delivery Systems
  Mohammad Hossein Karami Majid Abdouss Mohammadreza Kalaee Omid Moradi
  Hydrogels are three-dimensional networks of hydrophilic polymers capable of absorbing and retaining significant amounts of fluids, which are also widely applied in wound healing, cartilage tissue engineering, bone tissue engineering, release of proteins, growth factors, More

  Hydrogels are three-dimensional networks of hydrophilic polymers capable of absorbing and retaining significant amounts of fluids, which are also widely applied in wound healing, cartilage tissue engineering, bone tissue engineering, release of proteins, growth factors, and antibiotics. In the past decades, a lot of research has been done to accelerate wound healing. Hydrogel-based scaffolds have been a recurring solution in both cases, although their mechanical stability remains a challenge, some of which have already reached the market. To overcome this limitation, the reinforcement of hydrogels with fibers has been investigated. The structural similarity of hydrogel fiber composites to natural tissues has been a driving force for the optimization and exploration of these systems in biomedicine. Indeed, the combination of hydrogel formation techniques and fiber spinning methods has been very important in the development of scaffold systems with improved mechanical strength and medicinal properties. Hydrogel has the ability to absorb secretions and maintain moisture balance in the wound. In turn, the fibers follow the structure of the extracellular matrix (ECM). The combination of these two structures (fiber and hydrogel ) in a scaffold is expected to facilitate healing by creating a suitable environment by identifying and connecting cells with the moist and breathing space required for healthy tissue formation. Modifying the surface of fibers by physical and chemical methods improves the performance of hydrogel composites containing Manuscript profile
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  6 - Different fabrication methods and ideal properties of scaffolds for tissue engineering applications.
  Mohammad Rasouli Soheila Kashanian
  Tissue engineering is a science that uses the combination of scaffolds, cells and active biomolecules to make a tissue in order to restore or maintain the function and improve the damaged tissue or even an organ in the laboratory. Artificial skin and cartilage are among More

  Tissue engineering is a science that uses the combination of scaffolds, cells and active biomolecules to make a tissue in order to restore or maintain the function and improve the damaged tissue or even an organ in the laboratory. Artificial skin and cartilage are among the engineered tissues that have been approved by the US Food and Drug Administration (FDA) for clinical use. Accuracy in the design and fabrication of scaffolds with ideal properties such as biocompatibility, biodegradability, mechanical and surface properties is very important for applications in tissue engineering. Furthermore, these techniques should be able to translate the fabricated scaffolds from potential to actual applications. Several fabrication technologies have been used to design ideal 3D scaffolds with controlled nano- and micro-structures to achieve the ultimate biological response. This review highlights the applications and ideal parameters (biological, mechanical and biodegradability) of scaffolds for various biomedical and tissue engineering applications. This review discusses in detail the various design methods developed and used to design scaffolds, namely solvent casting/particle leaching, freeze drying, thermally induced phase separation (TIPS), gas foaming. (GF), powder foam, sol-gel, electrospinning, stereolithography (SLA), fused deposition modeling (FDM), selective laser sintering (SLS), jet binder technique, inkjet printing, laser-assisted bioprinting, writing It reviews direct cell and metal-based additive manufacturing, focusing on their advantages, limitations, and applications in tissue engineering. Manuscript profile