Application of stem cells and tissue engineering in wound management
Subject Areas : Wound, Complications and TreatmentsSaeed Farzad-Mohajeri 1 , Mahdi ghamsari 2
1 -
2 - Tehran University
Keywords: Wound management, Stem cells, Tissue Engineering, Scaffold,
Abstract :
Optimum healing of a cutaneous wound involves a cascade of biologic cellular and molecular processes. When the normal biological process fails for any reason, healing process can cease resulting in chronic wounds. In Addition, the body cannot repair some extensive wounds without problem. These Issues surrounding wound healing as well as increased medical healthcare in this field, developed novel wound therapies. Regardless of the type of these specific advanced wound care methods, the ideal goal would be to regenerate tissues such that both the structural and functional properties of the wounded tissue are restored to the levels before injury. Tissue engineering and stem cells may be the solution. A range of cell based therapies and tissue engineered scaffolds have begun to cross the rift from bench to bedside. These therapies have been heralded as a promising means by which to surpass current limitations in wound management. The wide differentiation potential of stem cells allows for the possibility of regenerating lost or damaged skin, while their ability to immunomodulate the wound bed from afar suggests that their clinical applications need not be restricted to direct tissue formation. The data suggests that the appropriate application of stem cells and scaffolds can accelerate wound healing. The clinical utility of stem cells and tissue engineering has been demonstrated across dozens of clinical trials in wound therapy.
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