Background: Cell adhesion molecules mediate leukocyte responses to inflammation. The purpose of study was to the effect of aerobic training and probiotic intake on ICAM–1 in rats with fatty liver. Materials and Methods: In this experimental study, 32 rats (200-250 gr) were randomly divided into four groups (healthy control, steatosis, steatosis + probiotic, steatosis + probiotic + training). To create a fatty liver model, tetracycline at a dose of 100 mg / kg in a volume of 1.5 cc was gavaged daily for two weeks. The training program includes 8 weeks and 5 sessions per week, in the initial week with a speed of 18 meters per minute, time started 10 minutes and every week quickly, 1-2 meters per minute and time was added to 10 minutes. Supplemental groups received 109 CFU / ml of Lactobacillus ramensus by gavage daily for 8 weeks and 5 days per week. Liver tissue samples were taken to examine the expression of ICAM-1 gene. 10 ml of blood was collected from the hearts of rats for ALP testing. The data was analyzed using one-way analysis of variance (ANOVA) p05/0≥. Results: The results showed that the aerobic training along with probiotic consumption significantly reduced the expression gene of ICAM-1 and ALP in rats with non-alcoholic fatty liver. Conclusion: It seems aerobic training combined with probiotic consumption improved the expression gene of ICAM-1 and ALP enzyme in the studied samples which can be effective in treating patients with fatty liver disease Manuscript profile

Background: Fatty liver disease is the most important reason for chronic liver diseases such as liver fibrosis, cirrhosis and liver cancer. The aim of this study was the effect of endurance training and probiotic consumption on IL-18 gene expression in male rats with steatosis. Materials and Methods: In this experimental study, 32 rats (average weight 200-250 grams) were randomly divided into four groups (healthy control, modeled (steatosis) group, steatosis + probiotic group, and steatosis + probiotic + exercise group). Training groups for 8 weeks, 5 sessions every week, in the beginning week with a speed of 18 meters per minute, time of 10 minutes, and every week the speed of 1-2 meters per minute and the time was increased by 10 minutes, so that In the fourth week, the speed reached 22 meters per minute and the time reached 40 minutes. The groups receiving the supplement received 109 CFU/ml of Lactobacillus rhamnus GG by gavage daily for 8 weeks and 5 days a week. IL-18 gene expression in liver tissue was measured by Real-time PCR method. The data were evaluated using the statistical method of one-way analysis of variance and significance level (P ≥ 0.05). Results: The results showed that endurance training along with probiotic consumption significantly decreased IL-18 gene expression in rats with steatosis. Conclusion: It seems that performing endurance training along with probiotic consumption can have a greater effect than the effect of probiotic alone on IL-18 gene expression. Manuscript profile