A Review on biodegradable elastomers: synthesis, advances and biomedical applications
Subject Areas :Mohammad Hossein Ahmadi 1 , jafar Khademzadeh Yeganeh 2
1 - 1Department of Polymer Engineering, Faculty of Engineering, Qom University of Technology, Qom, Iran
2 -
Keywords: Elastomer, biodegradable, polyester, polyurethane, Biomedical,
Abstract :
Biomedical remedial approaches and devices have been transformed by synthetic biodegradable elastomers like polyesters and polyurethanes. A number of biodegradable elastomers and related devices with controllable properties and various functionalities have been created as a result of technological advancements in synthesis and processing. Due to their relatively high maximum elongation and exceptional impact resistance, biodegradable elastomers are capable of withstanding and recovering from repeated deformations at either room temperature or body temperature. Their flexible texture and outstanding elasticity allow them to closely mimic the mechanical characteristics of soft native tissues, providing vital mechanical signals for tissue engineering structures. This study highlights the latest advancements in the synthesis methods, processing technologies, and biomedical applications of biodegradable elastomers which are mainly based on polyester and polyurethane. To meet the diverse needs of biomedical applications, multifunctional biodegradable elastomers are being developed with tailored mechanical properties, controlled biodegradation behavior, improved biocompatibility and bioactivity, as well as the incorporation of smart functionalities. We have then explored the use of biodegradable elastomers across various fields, including cardiovascular, nerve, and bone tissue engineering, as well as their application as bio-adhesives. Despite substantial advances, biodegradable elastomers continue to lack the sophisticated mechanical properties and diverse functionalities necessary for clinical use.
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