The Effect of an Aerobic Training Course with Curcumin Supplementation on Serum Lipid Profile in Obese Male Rats
Subject Areas : Exercise Training and Diseases
Somayeh Sadeghnia
1
(Department of Physical Education and Sport Sciences, Yazd Branch, Islamic Azad University, Yazd, Iran)
Abbas Fattahi Bafghi
2
(Department of Physical Education and Sport Sciences, Yazd Branch, Islamic Azad University, Yazd, Iran)
Narges shishebori
3
(Department of Physical Education and Sport Sciences, Yazd Branch, Islamic Azad University, Yazd, Iran)
Keywords: aerobic training, curcumin, lipid profile,
Abstract :
Background: Today, research has shown that the combination of physical activity and supplements can have more beneficial effects on diseases, so the purpose of this study is to investigate the effect of a period of aerobic training combined with consumption Curcumin supplement is based on serum lipid profile of obese rats. Materials and Methods: In a semi-experimental and applied study, 32 obese male rats of 6 months with Wistar breed with a weighted average of 332/28 Grams and standard deviation of 9 after 7 days of acquaintance with the laboratory environment were randomly divided into 4 groups of 8 (control, training, supplement and training-supplement). The training-supplementation and training groups underwent aerobic training for 6 weeks and 4 sessions in each week, according to the training protocol. Supplement and training- Supplements Groups also for 6 weeks and 4 meals every week, one hour before the start of training, 50 mg of curcumin per kilogram of body weight was gavage. 24 hours after the last training session, while fasting for 12 hours, all subjects were anesthetized with ketamine and xylazine solution and blood was taken from the posterior orbital sinus of the rats. The collected blood samples were immediately transferred to the laboratory to measure the variables. In order to analyze the data at the descriptive level, mean and standard deviation tests were used, and at the inferential level, the Shapiro-Wilk test was used to check the normality of the data, and the two-way ANOVA test was used to check the interaction effect of the groups. data analysis It was done with using spss software version 26 and at a significance level (P≤0.05). Results: The results of the research showed that a course of aerobic training and curcumin supplementation had a significant effect on TG and HDL of obese rats. It was also observed that a course of aerobic training and curcumin supplementation had no significant effect on TC and LDL of obese rats. Conclusion: The results showed that aerobic training and curcumin supplementation can be used simultaneously to improve the lipid profile of obese people, especially in HDL and TG indices
1. Unamuno X, Gómez-Ambrosi J, Rodríguez A, Becerril S, Frühbeck G, Catalán V. Adipokine dysregulation and adipose tissue inflammation in human obesity. Eur J Clin Invest. 2018 Sep;48(9):e12997. doi: 10.1111/eci.12997. Epub 2018 Aug 3. PMID: 29995306.
2. Riyahi Malayeri, S., Mirakhorli, M. The Effect of 8 Weeks of Moderate Intensity Interval Training on Omentin Levels and Insulin Resistance Index in Obese Adolescent Girls. Sport Physiology & Management Investigations, 2018; 10(2): 59-68.
3. Arabzadeh E, Shirvani H, Ebadi Zahmatkesh M, Riyahi Malayeri S, Meftahi GH, Rostamkhani F. Irisin/FNDC5 influences myogenic markers on skeletal muscle following high and moderate-intensity exercise training in STZ-diabetic rats. 3 Biotech. 2022 Sep;12(9):193. doi: 10.1007/s13205-022-03253-9. Epub 2022 Jul 26. PMID: 35910290; PMCID: PMC9325938.
4. Bonyadi, M., Abedi, B. The effect of aerobic training and pomegranate supplementation on lipid peroxidation and some adhesion molecules in obese women. Health and Development Journal, 2020; 8(4): 371-383. doi: 10.22034/8.4.371.
5. Hosseini M, Ghasem Zadeh Khorasani N, Divkan B, Riyahi Malayeri S. Interactive Effect of High Intensity Interval Training with Vitamin E Consumption on the Serum Levels of Hsp70 and SOD in Male Wistar Rats. Iranian J Nutr Sci Food Technol 2019; 13 (4) :21-28URL: http://nsft.sbmu.ac.ir/article-1-2689-en.html.
6. Balaguera-Cortes L, Wallman KE, Fairchild TJ, Guelfi KJ. Energy intake and appetite-related hormones following acute aerobic and resistance exercise. Appl Physiol Nutr Metab. 2011 Dec;36(6):958-66. doi: 10.1139/h11-121. Epub 2011 Nov 23. PMID: 22111518.
7. Shepherd SO, Wilson OJ, Taylor AS, Thøgersen-Ntoumani C, Adlan AM, Wagenmakers AJ, Shaw CS. Low-Volume High-Intensity Interval Training in a Gym Setting Improves Cardio-Metabolic and Psychological Health. PLoS One. 2015 Sep 24;10(9):e0139056. doi: 10.1371/journal.pone.0139056. PMID: 26402859; PMCID: PMC4581708.
8. Okdan B, Nalcakan GR, Onur E, Oran A, Nalcakan M. effect of folk dance training on blood oxidative stress level, lipids, and lipoproteins. Polish Journal of Sport and Tourism. 2016;23(3):133-9. doi.10.1136/bjsports-2016- 097120.40.
9. Fakhri F, Fakhri S, Shakeryan S, Alizadeh A. The Effect of Short–Term Nanocurcumin Supplementation on the Anthropometric Indices, Lipid Profile and C-Reactive Protein of Overweight Girls. cmja 2020; 10 (1) :94-105.
10. Naghizadeh N, Riyahi Malayeri S, Roozbahani M, Khademi A, Shirvani H. The Effectiveness of Endurance Training and Nano Curcumin Consumption on Short-Term Memory in Mice with Glioblastoma Multiforme Brain Tumor. J Mazandaran Univ Med Sci 2023; 33 (226) :28-40.URL:http://jmums.mazums.ac.ir/article-1-19767-en.html.
11. Hossini, S. Effects of Aerobic Exercise and Curcumin on Apoptosis: A Review. Pars Journal of Medical Sciences, 2022; 16(2): 58-66. doi: 10.52547/jmj.16.2.58.
12. Pathomwichaiwat T, Jinatongthai P, Prommasut N, Ampornwong K, Rattanavipanon W, Nathisuwan S, Thakkinstian A. Effects of turmeric (Curcuma longa) supplementation on glucose metabolism in diabetes mellitus and metabolic syndrome: An umbrella review and updated meta-analysis. PLoS One. 2023 Jul 20;18(7):e0288997. doi: 10.1371/journal.pone.0288997. PMID: 37471428; PMCID: PMC10359013.
13. Salehi A, Abbaszadeh H, Farzanegi P. The Effect of Periodic Exercise and Resveratrol Supplementation on the Expression of Pparg Coactivator-1 Alpha and Pyruvate Dehydrogenase Kinase Genes in Gastrocnemius Muscle of Old Rats With Type 2 Diabetes. Intern Med Today 2019; 26 (1) :68-81.
14. Fattahi Bafghi, A., Homaee, H. M., & Azarbayjani, M. A. (2016). Effects of high intensity interval training and curcumin supplement on antioxidant enzyme in heart tissue of diabetic rats. Iranian Journal of Diabetes and Obesity, 8(3), 135-141.
15. Amirkhani, Z, Azarbaijani, M A, Piri, M, & Metin Homai, H. (2016). The effect of resistance training with curcumin consumption on the lipid profile of obese women. Iranian Journal of Women, Midwifery and Infertility, 20(9), 24-32. doi: 10.22038/ijogi.2017.
16. Tabrizi R, Vakili S, Lankarani KB, Akbari M, Mirhosseini N, Ghayour-Mobarhan M, Ferns G, Karamali F, Karamali M, Taghizadeh M, Kouchaki E, Asemi Z. The Effects of Curcumin on Glycemic Control and Lipid Profiles Among Patients with Metabolic Syndrome and Related Disorders: A Systematic Review and Metaanalysis of Randomized Controlled Trials. Curr Pharm Des. 2018;24(27):31843199. doi:10.2174/1381612824666180828162053. PMID: 30156145.
17. Amirsasan, R., Piralaiy, E., Lotfi, F., Armanfar, M. The Effect of Rhythmic Aerobic Exercise and Curcumin Supplementation on Some Lipid Profile and Oxidative Stress Indicators in Inactive Overweight and Obese Women. Journal of Sport Biosciences, 2023; 15(3): 37-49. doi: 10.22059/jsb.2023.356247.1580
18. Naghizadeh, H., Heydari, F. The effect of 12 weeks of HIIT and curcumin consumption on oxidative indices in obese men with type-2 diabetes mellitus. Journal of Sport and Exercise Physiology, 2022; 15(4): 67-81. doi: 10.52547/joeppa.15.4.67
19. abdi A. The effect of aerobic training with coriander seed extract on lipoprotein A-1, Lipid Profile and Insulin Resistance in streptozotocin-induced diabetic rats. cmja 2017; 7 (3) :1989-2000.
20. Kadkhoda Z, Khajeie R, Barjaste Yazdi A, Safipor Afshar A, Zarei M. Effect of Eight Weeks of High-Intensity Interval Training Along With Purslane Consumption on Lipid Profile of Rats with Non-alcoholic Fatty Liver Disease. cmja 2022; 12 (3) :270-283.
21. Dolati S, Namiranian K, Amerian R, Mansouri S, Arshadi S, Azarbayjani MA. The Effect of Curcumin Supplementation and Aerobic Training on Anthropometric Indices, Serum Lipid Profiles, C-Reactive Protein and Insulin Resistance in Overweight Women: A Randomized, Double-Blind, Placebo-Controlled Trial. J Obes Metab Syndr. 2020 Mar 30;29(1):47-57. doi: 10.7570/jomes19055. PMID: 32145720; PMCID: PMC7118005.
