Background: Today, research has shown that the combination of physical activity and supplements can have more beneficial effects on diseases, so the purpose of this study is to investigate the effect of a period of aerobic training combined with consumption Curcumin supplement is based on serum lipid profile of obese rats. Materials and Methods: In a semi-experimental and applied study, 32 obese male rats of 6 months with Wistar breed with a weighted average of 332/28 Grams and standard deviation of 9 after 7 days of acquaintance with the laboratory environment were randomly divided into 4 groups of 8 (control, training, supplement and training-supplement). The training-supplementation and training groups underwent aerobic training for 6 weeks and 4 sessions in each week, according to the training protocol. Supplement and training- Supplements Groups also for 6 weeks and 4 meals every week, one hour before the start of training, 50 mg of curcumin per kilogram of body weight was gavage. 24 hours after the last training session, while fasting for 12 hours, all subjects were anesthetized with ketamine and xylazine solution and blood was taken from the posterior orbital sinus of the rats. The collected blood samples were immediately transferred to the laboratory to measure the variables. In order to analyze the data at the descriptive level, mean and standard deviation tests were used, and at the inferential level, the Shapiro-Wilk test was used to check the normality of the data, and the two-way ANOVA test was used to check the interaction effect of the groups. data analysis It was done with using spss software version 26 and at a significance level (P≤0.05). Results: The results of the research showed that a course of aerobic training and curcumin supplementation had a significant effect on TG and HDL of obese rats. It was also observed that a course of aerobic training and curcumin supplementation had no significant effect on TC and LDL of obese rats. Conclusion: The results showed that aerobic training and curcumin supplementation can be used simultaneously to improve the lipid profile of obese people, especially in HDL and TG indices Manuscript profile