Circulating concentrations of the BATokine 12,13-dihydroxy- 9Z-octadecenoic acid (12,13-diHOME) in different types of exercise training
Subject Areas : Sport Physiology
Mehdi Zargani
1
(Department of Exercise Physiology, Islamic Azad University, Karaj Branch, Karaj, Alborz, Iran)
Ehsan Arabzadeh
2
(Exercise Physiology Research Center, Life Style Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran.)
Fariba Aghaei
3
(Clinical Care and Health Promotion Research Center, Karaj branch, Islamic Azad University, Karaj, Iran )
Yosef Ebrahimpour
4
(Exercise Physiology Research Center, Life Style Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran.)
Keywords: BATokine, Exercise, Fat,
Abstract :
According to the investigation, Lipokines are a kind of bioactive compounds, derived from adipose tissue deposition, which manages multiple molecular signaling pathways. In recent years, 12,13-dihydroxy-9Z-octadecanoic acid (12,13-diHOME), an Oxylipin, has become increasingly important in the scientific literature. An increase of 12,13-diHOME in circulation was associated with an improvement in metabolic health, and the action of this molecule seems to be mediated by brown adipose tissue (BAT)(1). In fact, Oxylipins are oxidized metabolites of long-chain polyunsaturated fatty acids (PUFAs). PUFAs may be received immediately from the weight loss program or from the metabolism of linoleic acid and α-linolenic acid(2). Research indicates that Oxylipins are present in every tissue, urine and blood(3). Linoleic acid may be metabolized through cytochrome P450 (CYP) in order to produce 12,13-diHOME(4). Circulating concentrations of BATokine 12,13-dihydroxy-9Z-octadecenoic (12,13-diHOME) in rodents and humans have been shown to be elevated following exposure to cold and exercise. In other words, in mice, administration of 12,13-diHOME increased fatty acid absorption by brown/beige adipocytes and skeletal muscle after a session of moderate-intensity training, and in rodents using the same training protocol. Furthermore, investigation suggests that circulating 12,13-diHOME is associated with an increase in mitochondrial respiration capacity in the skeletal muscle. This information improves the opportunity that will increase in circulating 12,13-diHOME with exercising capabilities to assist expand the respiratory capacity of a training skeletal muscle and might increase exercise potential(5,6).
1. Macêdo APA, Muñoz VR, Cintra DE, Pauli JR. 12, 13-diHOME as a new therapeutic target for metabolic diseases. Life Sciences. 2021:120229. https://doi.org/10.1016/j.lfs.2021.120229
2. Yang YR, Kwon KS. Potential Roles of Exercise-Induced Plasma Metabolites Linking Exercise to Health Benefits. Front Physiol. 2020 Dec 3; 11:602748. doi: 10.3389/fphys.2020.602748. PMID: 33343398; PMCID: PMC7744613.
3. Gabbs M, Leng S, Devassy JG, Monirujjaman M, Aukema HM. Advances in Our Understanding of Oxylipins Derived from Dietary PUFAs. Adv Nutr. 2015 Sep 15;6(5):513-40. doi: 10.3945/an.114.007732. PMID: 26374175; PMCID: PMC4561827.
4. Hildreth K, Kodani SD, Hammock BD, Zhao L. Cytochrome P450-derived linoleic acid metabolites EpOMEs and DiHOMEs: a review of recent studies. J Nutr Biochem. 2020 Dec; 86:108484. doi: 10.1016/j.jnutbio.2020.108484. Epub 2020 Aug 20. PMID: 32827665; PMCID: PMC7606796.
5. Lynes MD, Leiria LO, Lundh M, Bartelt A, Shamsi F, Huang TL, et al. The cold-induced lipokine 12,13-diHOME promotes fatty acid transport into brown adipose tissue. Nat Med. 2017 May;23(5):631-637. doi: 10.1038/nm.4297. Epub 2017 Mar 27. Erratum in: Nat Med. 2017 Nov 7;23 (11):1384. PMID: 28346411; PMCID: PMC5699924.
6. Stanford KI, Lynes MD, Takahashi H, Baer LA, Arts PJ, May FJ, et al. 12,13-diHOME: An Exercise-Induced Lipokine that Increases Skeletal Muscle Fatty Acid Uptake. Cell Metab. 2018 May 1;27(5):1111-1120.e3. doi: 10.1016/j.cmet.2018.03.020. Erratum in: Cell Metab. 2018 Jun 5;27(6):1357. PMID: 29719226; PMCID: PMC5935136.
