List of Articles Stem cells

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  1 - Application of stem cells and tissue engineering in wound management
  Saeed Farzad-Mohajeri Mahdi ghamsari
  Optimum healing of a cutaneous wound involves a cascade of biologic cellular and molecular processes. When the normal biological process fails for any reason, healing process can cease resulting in chronic wounds. In Addition, the body cannot repair some extensive wou More

  Optimum healing of a cutaneous wound involves a cascade of biologic cellular and molecular processes. When the normal biological process fails for any reason, healing process can cease resulting in chronic wounds. In Addition, the body cannot repair some extensive wounds without problem. These Issues surrounding wound healing as well as increased medical healthcare in this field, developed novel wound therapies. Regardless of the type of these specific advanced wound care methods, the ideal goal would be to regenerate tissues such that both the structural and functional properties of the wounded tissue are restored to the levels before injury. Tissue engineering and stem cells may be the solution. A range of cell based therapies and tissue engineered scaffolds have begun to cross the rift from bench to bedside. These therapies have been heralded as a promising means by which to surpass current limitations in wound management. The wide differentiation potential of stem cells allows for the possibility of regenerating lost or damaged skin, while their ability to immunomodulate the wound bed from afar suggests that their clinical applications need not be restricted to direct tissue formation. The data suggests that the appropriate application of stem cells and scaffolds can accelerate wound healing. The clinical utility of stem cells and tissue engineering has been demonstrated across dozens of clinical trials in wound therapy. Manuscript profile
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  2 - The effect of endurance training and mesenchymal stem cells on ALP gene expression and osteopontin levels in rats with knee osteoarthritis
  Marjan Haghjoo Mohammad Ali  Azarbayjani Seyed Ali  Hosseini Maghsoud   Peeri
  Background: Osteoarthritis (arthritis of the joints) is one of the most common metabolic disorders of bone tissue that reduces the process of absorption and reabsorption in bone. Exercise and stem cell injections can have beneficial effects in treating this disease. The More

  Background: Osteoarthritis (arthritis of the joints) is one of the most common metabolic disorders of bone tissue that reduces the process of absorption and reabsorption in bone. Exercise and stem cell injections can have beneficial effects in treating this disease. The enzymes alkaline phosphatase and osteopontin, as markers of bone formation, play an important role in diagnosing the progression or treatment of this disease. The aim of this study was to examine the effect of training, stem cells and hyaluronic acid on osteocalcin, ALP and osteopontin in the cartilage tissue of rats with osteoarthritis. Materials and Methods: In this study, 25 rats were divided in 5 groups including: (1) healthy control, (2) patient control, (3) endurance training (3 days a week for one month), (4) recipients of mesenchymal stem cells (1 × 106 cells / Kg), and (5) simultaneous recipients of endurance training and mesenchymal stem cells. Alkaline phosphatase gene expression was assessed by RT PCR and the amount of osteopontin synthesis was measured by immunohistochemistry procedure. Results: Training and mesenchymal stem cell injection had a significant effect on increasing alkaline phosphatase gene expression and osteopontin in patient rats compared to the patient control group (P <0.001). Also, simultaneous endurance training and stem cell injection have interactive effects on increasing both factors (P <0.001). Conclusion: Based on the findings of this study, it seems that endurance training and injection of mesenchymal stem cells in the joints, either separately or simultaneously, can increase the expression of alkaline phosphatase gene and the amount of osteopontin. Manuscript profile
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  3 - Different fabrication methods and ideal properties of scaffolds for tissue engineering applications.
  Mohammad Rasouli Soheila Kashanian
  Tissue engineering is a science that uses the combination of scaffolds, cells and active biomolecules to make a tissue in order to restore or maintain the function and improve the damaged tissue or even an organ in the laboratory. Artificial skin and cartilage are among More

  Tissue engineering is a science that uses the combination of scaffolds, cells and active biomolecules to make a tissue in order to restore or maintain the function and improve the damaged tissue or even an organ in the laboratory. Artificial skin and cartilage are among the engineered tissues that have been approved by the US Food and Drug Administration (FDA) for clinical use. Accuracy in the design and fabrication of scaffolds with ideal properties such as biocompatibility, biodegradability, mechanical and surface properties is very important for applications in tissue engineering. Furthermore, these techniques should be able to translate the fabricated scaffolds from potential to actual applications. Several fabrication technologies have been used to design ideal 3D scaffolds with controlled nano- and micro-structures to achieve the ultimate biological response. This review highlights the applications and ideal parameters (biological, mechanical and biodegradability) of scaffolds for various biomedical and tissue engineering applications. This review discusses in detail the various design methods developed and used to design scaffolds, namely solvent casting/particle leaching, freeze drying, thermally induced phase separation (TIPS), gas foaming. (GF), powder foam, sol-gel, electrospinning, stereolithography (SLA), fused deposition modeling (FDM), selective laser sintering (SLS), jet binder technique, inkjet printing, laser-assisted bioprinting, writing It reviews direct cell and metal-based additive manufacturing, focusing on their advantages, limitations, and applications in tissue engineering. Manuscript profile