The effect of aerobic exercise on JAK/STAT signaling pathway
Subject Areas : Sport Physiology
Amir Hesam Salmasi Fard
1
,
Mohammad Ali Azarbayjani
2
,
Farhad Riazi Rad
3
,
maghsoud peeri
4
,
Hasan Matin Homaee
5
1 -
2 -
3 -
4 - 1. Department of Sports Physiology, Central Tehran Branch, Islamic Azad University, Tehran, Iran
5 -
Keywords: aerobic exercise, JAK, STAT,
Abstract :
JAK/STAT is one of the key pathways in cell proliferation, growth, and differentiation. In most tissues, this path is known as the cause of inflammation and, in some cases, the induction and progression of diseases. In contrast, aerobic exercise regulates and modulates cell signaling by affecting signaling pathways and inflammatory and pro-inflammatory cytokines. In this article, we investigate the effect of aerobic exercise on the JAK/STAT signaling pathway.Classified articles were searched from reliable international and Iranian scientific databases. Articles were extracted from scientific databases such as Pubmed, Scopus, Science Direct, and Google Scholar. Also, articles were extracted from the scientific databases of Iran Magiran, SID, and Civilica. Out of 45 articles, 13 met this review article's criteria. Aerobic exercise affects the JAK/STAT signaling pathway in various tissues and organs. According to research results, aerobic exercise activates or inhibits this pathway differently depending on the tissue type. These effects of aerobic exercises were different in research tissues and models.Therefore, we emphasize the importance of further research on this signaling pathway and its response to exercise, especially aerobic exercise, to fully understand its effects and consequences. This research is necessary and significant in the field of exercise physiology and immunology.
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