Interventional (Experimental) Studies in Veterinary Research & Practice
Subject Areas : Other Related Sciences
Alireza Bahonar
1
,
Marzieh Faezi
2
,
Zahra Boluki
3
1 - Tehran University
2 - Specialty Bored Certified in Veterinary Epidemiology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran.
3 - PhD of Veterinary Epidemiology, Member of Iranian Epidemiological Association, Tehran, Iran
Keywords: Interventional study, Experimental Study, laboratory study, blinding, medical ethics,
Abstract :
Interventional studies , especially in laboratory experimental researches , constitute a significant portion of the theses conducted in veterinary faculties across the country . The importance of these study designs in applied research and development underscores the necessity for students and researchers to be familiar with this design . This article begins with a brief history of this type of study . It then proceeds to introduce various types ( laboratory , clinical trials , field trials , social trials , quasi-experimental studies ) , the different phases of this design ( pharmacological and toxicity testing , initial testing for potential therapeutic and safety effects , clinical evaluation stage , post-marketing evaluation ) , and its various methods (parallel design , crossover design , sequential design , factorial design ) . This article also discusses the required sample size for conducting a study , criteria for entry and exit of study participants or animals , blinding and medical ethics . Given the importance of clinical trials , especially in terms of ethical considerations in research , the registration of this type of study after proposal development is also mentioned . This article refers to some examples of interventional studies published in Iran and worldwide so that students and researchers can use these designs as models . It is expected that the reader could critically read these type of articles and reports , published in scientific texts and play an effective role in conducting an experimental ( interventional ) study .
1- Thrusfield M. Veterinary Epidemiology, 4th edition, John Wiley & Sons; 2018.
2- Dohoo I, Martin W, Stryhn H. Veterinary Epidemiologic Research. 2nd ed, VER Inc; 2009.
3- Malekafzali H, Majdzadeh R, Fotouhi A, Tavakoli S. Methodology of Applied Rsearches in Medical Sciences (in Persian), 1st edition, Tehran: Tehran University of Medical Sciences; 2004.
4- Gordis L. Epidemiology, 6th edition, Gap; 2013.
5- Mausner JS, Bahn AK. Epidemiology Principals: Iran university press; 1994.
6- Park JE. Textbook of Preventive and Social Medicine: a Treatise on Community Health. 17th ed: Samat publication; 2002.
7- Akbarein H, Bahonar AR, Nekouei Jahromi OA, Sharifi H,. Evaluation of published articles in the Journal of the Faculty of Veterinary Medicine, University of Tehran between 2000 and 2009. Iranian Journal of Epidemiology. 2011;7(1):1-6.
8- Erfanmanesh A, Shokri H. Hassan J, Nikaein D, Gharibi S, Bahonar AR, Khosravi AR. Evaluation of anti-candida properties of cationic peptides derived from rana ridibunda skin. Journal of Veterinary Research. 2015;70(2):119-24.
9- Naeimi S, Sadeghi-hashjin G, Meurs H, Vojgani M, Muhammadnejad S, Bahonar AR, et al. Effects of experimental thyroid dysfunction on the reactivity of isolated tracheal smooth muscle in the guinea pig. World Applied Sciences Journal. 2012;16(10):1398-02.
10- Ahrari Khafi MS, Soroori S, Nakhjavani M, Mortazavi P, Vajhi AR, Bahonar AR. The effects of growth hormone administration on bone density in healthy adult rabbits. Tehran Univ Med J. 2011;69(1):10-15.
11- Katiraee F, Eidi s, Bahonar AR, Zarrinfar H, Khosravi AR. Comparision of mics of some iranian herbal essences against azole resistance and azole susceptible of candida albicans. Journal of Medicinal Plants. 2008;27(7):37-44.
12- Bahramiyan F, Ghiassi Tarzi B,Yaghmaei S, Bahonar AR. Extraction of plum phenolic compounds using different solvents - the antimicrobial effect of the extracts on the growth of e.coli and s. Aureus. Journal of Food Technology & Nutrition. 2012;9(1):73.
13- Najafi momen R, Torabi goudarzi M, Bahonar AR, Akbari H, Darabi M. Clinical evaluation of the effect of myrtle oil on the oral lesions of fmd in cattle. Journal of Medicinal Plants. 2011;38(10):135-41.
14- Torabi goudarzi M, Bahonar AR, Raoufi A, Akbari H, Haghi Gh. Clinical evaluation of chicory (Cichorium intybus L.) and anise (Pimpinella anisum L.) on cattle appetite and comparison with common product. Iranian Journal of Medicinal and Aromatic Plants Research. 2010;48(2):275-82.
15- Khalaj M, Nabian S, Nourelahi FA, Bahonar AR, Rahbari S. Field efficacy evaluation of cypermethrine and cyhalothrine acaricides against hyalomma tick. Iranian Veterinary Journal. 2009;23(5):89-93.
16- Sattari A, Mirzargar SS, Abrishamifar A, Lourakzadegan R, Bahonar A, Ebrahimzadeh Mousavi HA, et al. Comparison of electroanesthesia with chemical anesthesia (MS222 and clove oil) in rainbow trout (Oncorhynchus mykiss) using plasma cortisol and glucose responses as physiological stress indicators. .Asian Journal of Animal and Veterinary Advances. 2009(4):306-13. https://doi.org/10.3923/ajava.2009.306.313
17- Mardani A. Studies in medical science researches 2021 [available from: https://medlabnews.ir/]
18- Vojgani M, Gharahgouzlou F, Bahonar AR, Darabi M, Jafari H. Evaluation of therapeutic effects of topical application of eucalyptus essential oil (essence) on experimental mastitis caused by streptococcus agalactiae. Iranian Veterinary Journal. 2006;12(10):5-14.
19- Mosalanezhad B, Malmasi AA, Mohebali M, Tabatabaei M, Bahonar AR, Sasani F. Inhibitory effects of clindamycin on shedding of toxoplasma gondii oocyst and its comparison with monensin in kitten. Archives of Razi Institute. 2006;61(1):35-41.
20- Mohammad Sadegh M, Shalizar Jalali M, Bahonar AR, Erfanmanesh A. Comparison between two chlorine disinfectants as a post milking teat dip in dairy cows. Journal of Veterinary Research. 2007;62(5):269-72.
21- Soltani M, Esfandiary M, Sajadi MM, Khazraeenia S, Bahonar AR, Ahari H. Effect of nanosilver particles on hatchability of rainbow trout (oncorhynchus mykiss) egg and survival of the produced larvae. Iranian Journal of Fisheries Sciences. 2011;10(1):167-78.
22- Sharifrohani M, Ebrahimzadeh Mousavi HA, Khosravi AR, Mokhayer B, Mirzargar SS, Mehrabi Yad E. Evaluation of geranium herbarum escence application in control of fungal contamination in rainbow trout eggs. Journal of Veterinary Research. 2006;3(61):269-72.
23- Soukhtezari A, Vojgani M, Niassari Naslaji A, Bahonar AR, Gholami GR. Influence of Melatonin Treatment on Scrotal Circumference and Semen Parameters in Shall Rams on out of Season. Journal of Veterinary Research. 2008;63(4):297-300.
24- Youssefi R, Vojgani M, Gharegozloo F, Bolourchi M, Bahonar AR. Evaluation of the effect of presynch ovsynch program on reproductive performance of dairy cows with retained fetal membrane. Journal of Veterinary Research. 2013;68(2):143-50. https://doi.org/10.22059/jvr.2013.31961
25- Vojgani M, Mosanan A, Hasanlou J, Gharaghozlou F, Bahonar AR. Effect of PGF2α injection on conception rate of insemenated repeat breeder cows during summer warm condition. Journal of Veterinary Research. 2010;4(65):319-22.
26- Mousavi SM, Mirzargar SS, Ebrahimzadeh Mousavi HA, Omid Baigi R, Khosravi AR, Bahonar AR, et al. Evaluation of antifungal activity of new combined essential oils in comparison with malachite green on hatching rate in rainbow trout (oncorhynchus mykiss) eggs. Journal of Fisheries and Aquatic Science. 2009;4:103-10. https://doi.org/10.3923/jfas.2009.103.110
27- Saffarian AR, Rokni N, Akhondzadeh Basti A, Bahonar AR, Ebrahimzadeh Mosavi HA, Nouri N. Effects of gammairradiation and frozen storage on microbial, chemicaland sensory qualityoffish fillet. Journal of Veterinary Research. 2008;63(2):113-5.
28- Mokhtarnazif S, Smid AC, Weary DM, Mohamadnia A, Von Keyserlingk M. Motivation to walk affects gait attributes. J Dairy Sci. 2020;103(10):9481-7. 10.3168/jds.2019-18060
29- Shokri H, Asadi F, Bahonar AR, Khosravi AR The role of Zataria multiflora essence (iranian herb) on innate immunity of animal model. Iranian Journal of Immunology. 2006;3(4):164-8.
30- Larsen I, Hjulsager CK, Holm A, Olsen JE, Nielsen SS, Nielsen JP. A Randomised Clinical Trial on the efficacy of oxytetracycline dose through water medication of nursery pigs on diarrhoea, faecal shedding of lawsonia intracellularis and average daily weight gain. Preventive Veterinary Medicine. 2016;123:52-9. https://doi.org/10.1016/j.prevetmed.2015.12.004
31- Ariza JM, Bareille N, Lehebel A, Oberle K, Relun A, Guatteo R. Evaluation of a biocide footbath solution in the occurrence and healing of digital dermatitis lesions in dairy cows: a clinical trial. Preventive Veterinary Medicine. 2019;163:58-67. https://doi.org/10.1016/j.prevetmed.2018.12.017
