The Effect of Aerobic Training and Octopamine Supplement on Gene Expression Levels of VEGF and PDGFR in the Heart Tissue of Rats Exposed to Deep Fried Oil
Subject Areas : Sport Physiology
Faegheh Jafari Amoli
1
(Department of Sports Physiology, Central Tehran Branch, Islamic Azad University, Tehran, Iran.)
Seyed Ali Hosseini
2
(Department of Sports Physiology, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran.)
Mohammad Ali Azarbayjani
3
(Department of Sports Physiology, Central Tehran Branch, Islamic Azad University, Tehran, Iran.)
Parvin Farzanegi Arkhazloo
4
(Department of Exercise Physiology, Sari Branch, Islamic Azad University, Sari, Iran.)
Keywords: Deep Fried Oils, Aerobic Training, Octopamine, VEGF, PDGFR.,
Abstract :
Background: Deep-fried oils (DFO) produce toxins that endanger people's health. Using herbal supplements along with exercise training can help improve health. The purpose of this study was to investigate the effect of aerobic training (T) and octopamine (O) supplementation on VEGF and PDGFR gene expression levels in the heart tissue of rats poisoned with DFO. Materials and Methods: In this experimental study, 25 male Wistar rats were purchased and placed in 5 groups of 5 animals, including: 1) control, 2) DFO, 3) DFO+T, 4) DFO+O and 5) DFO+T+O. Over a course of 4 weeks, rats in groups 2 to 5 received DFO by gavage, and rats in groups 3 and 5 ran on the treadmill 5 times a week with moderate intensity; also, rats in groups 4 and 5 received 81 μmol/kg octopamine supplement intraperitoneally 5 days a week. The Kolmogorov-Smirnov statistical test, independent samples t-test and two-way analysis of variance were used to analyze the research findings (p<0.05). Results: DFO had a significant effect on increasing the gene expression levels of VEGF (p=0.001) and PDGFR (p=0.002); training had a significant effect on the reduction of VEGF (p=0.001) and PDGFR (p=0.012); also, octopamine consumption had a significant effect on the reduction of VEGF (p=0.001) and PDGFR (p=0.045). Conclusion: It seems that aerobic training and octopamine consumption alone have anti-inflammatory effects in the heart tissue of DFO-poisoned rats, however they do not have significant anti-inflammatory interactive effects.
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