Background: Irisin is released from the Fndc5 protein in muscle cell through physical activity and effects on metabolism through browning of white fat. The purpose of this study was to the effect of resistance training and supplementation of nanocurcumin on the expression of genes of FNDC5 and PPARɣ rat muscle tissue. Materials and Methods: In this experimental study, 32 rats were randomly divided into four groups (Control, resistance training, nanocurcumin, resistance training + nanocurcumin). The training groups program included 4 weeks, 3 days a week from climbing on a stepladder. Nanocarcmine (80 mg / kg) was given gavage in complementary groups for four weeks daily. FNDC5 and PPARƔ gene expression were measured using the RT-PCR method. Data were analyzed using one-way ANOVA with a significant level of P≤0.05. Results: The results showed that resistance training and supplementation of Nanocarcmine significantly increased the expression of the gene of FNDC5 and PPARɣ in muscle tissue of rat (P <0.05). Conclusion: It seems resistance training with nanocurcumin supplementation may stimulate secretion of FNDC5 & PPARƔ from muscle, that has a key role in the metabolism of adipose tissue and the conversion of white tissue to brown fat tissue. پرونده مقاله