Background: Visfatin is a new adipocyte which is highly expressed in visceral adipose tissue and has similar ‎effects with insulin in the body. The purpose of this study was to investigate the effect of moderate intensity‏ ‏interval training on visfatin and insulin resistance index in obese girls.‎ Material and Methods‏: ‏In this semi-experimental study, 18 obese girls aged 12 -14 years were selected ‎voluntarily and divided into two groups: training and control randomly. The training program included 8 weeks, ‎‎3 sessions a week, each week for 30 minutes running at 70% of the target heart rate in the first week to the fourth ‎week and 75% in the fifth to the eight weeks. Blood samples were taken 24 hours before and ‎‏48 ‏hours after the ‎training program and the research variables were measured using specific methods. Analysis of covariance ‎ANCOVA was used. The significance level was considered as p <0.05.‎ Results‏:‏‎.The results of the current paper showed that the visfatin , Insulin resistance index, insulin and maximal ‎oxygen consumption (vo2max) were increased in experimental group, which was significant only for the values ‎of vo2max (P = 0.001). Body weight, body fat percentage, body mass index or BMI and glucose variables ‎decreased in the experimental group.‎ Conclusion‏: ‏‎ Today obesity is become a worldwide health issue and in this research paper we could show that longer ‎training sessions with adequate intensity and volume have beneficial effects and they are suggested to make ‎optimal changes in visfatin levels and reduce insulin resistance in obese girl.‎ پرونده مقاله