Background: The purpose of this study was to investigate the effect of eight weeks of resistance training on the improvement or prevention of cardiac fibrosis in elderly rats. Main Topic this study was to investigate the effect of eight weeks of resistance training on the rehabilitation or prevention of cardiac fibrosis in elderly rats. Materials and Methods: In this experimental study, 18 Wistar rats with mean age of 24 months were randomly divided into control and endurance training groups (9 rats in each group). After a week of familiarization and adaptation, the experimental group performed their training program on a rats' resistance training ladder for 8 weeks and 5 days per week. The control group did not perform any exercise during this time. Research variables were measured by ELISA method and histological tests by trichrome-staining. For inferential analysis of data from independent t-test was used. Results: The results showed that eight weeks of aerobic training had a significant effect on SOD (P = 0.001), CAT (P = 0.006), GPX (P = 0.012), TGF (P = 0.001) and Tissue collagen in cardiac tissue of elderly rats. It has. Conclusion: The results of the present study confirm the positive role of resistance training in improving cardiac fibrosis due to collagen depletion due to TGF-β inhibition and its signaling pathway due to the improvement of cardiac tissue antioxidant enzymes. These exercises can be used to rehabilitate or prevent cardiac fibrosis. پرونده مقاله