اثربخشی تحریک جریان مستقیم فراجمجمه‌ای (tDCS) بر عملکرد حافظه کاری در افراد سالم
محورهای موضوعی :نیما گنجی 1 , رزا راشدی 2 , نگار کریمی 3 , پروانه فرهاد بیگی 4 , علی اکبر سلیمانی 5 , اعظم نوفرستی 6 , محمد حسین عبدالهی 7 , فاطمه معین الغربایی 8
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کلید واژه: حافظه کاری, تحریک الکتریکی مستقیم فراجمجمه ای (tDCS), قشر پیش‌پیشانی خلفی‌جانبی (DLPFC),
چکیده مقاله :
مقدمه: حافظه کاری یکی از توانمندی‌های شناختی بنیادین است که ما را در انجام پردازش‌های ذهنی پیچیده یاری می‌‌کند اما دارای ظرفیت محدودی است. دانشمندان در پی راه‌کارهایی جهت بالابردن ظرفیت حافظه کاری هستند. مطالعات فراوانی تأثیر تحریک مستقیم فراجمجمه‌ای (tDCS) را بر جنبه‌های مختلف عملکرد نشان داده است. هدف از این پژوهش بررسی اثربخشی تحریک جریان مستقیم فراجمجمه‌ای بر عملکرد حافظه کاری در افراد سالم است. روش: در این مطالعه به‌طور مشخص تأثیر دوره تحریک سه جلسه‌ای tDCS آندی با شدت 2 میلی‌آمپر در ناحیه قشر پیش‌پیشانی خلفی جانبی بر روی عملکرد حافظه کاری افراد سالم در دو گروه تصادفی آزمایشی و گواه با استفاده از آزمون n-back موردبررسی قرار گرفت. یافته‌ها: نتایج حاکی از آن بود که آزمودنی‌ها پس از سه جلسه تحریک مستقیم فراجمجمه‌ای، نسبت به قبل از مداخله تعداد پاسخ‌های درست‌تری (00/0P=) را در زمان کمتر (00/0P=) در آزمون n-back ارائه دادند. آزمودنی ها در گروه گواه که تحریک شم را دریافت کردند، تفاوت معناداری در نتایج نشان ندادند. نتیجه‌گیری: معناداری نتایج در آزمون n-back قبل و بعد از مداخله tDCS، نشان می‌دهد تحریک فراجمجمه‌ای آندی بر روی قشر پیش‌پیشانی خلفی‌جانبی موجب بهبود عملکرد حافظه کاری در آزمودنی‌های سالم می‌گردد.
Introduction: Working memory is one of the fundamental cognitive ability that helps us perform complex mental processes but has limited capacity. Scientists are looking for ways to increase working memory capacity. Numerous studies have shown the effect of direct transcranial stimulation (tDCS) on various aspects of performance. The aim of this study was to evaluate the effectiveness of transcranial direct current stimulation on working memory function in healthy individuals. Methods: In this study, the effect of three-session of anodal tDCS stimulation period with an intensity of 2 mA in the lateral posterior anterior cortex on the working memory function of healthy individuals in two experimental and control random groups was investigated using N-Beck test. Results: The results showed that the subjects in the experimental group after three sessions of direct transcranial stimulation, presented a higher number of correct answers (p= 0.00) in less response time (p=0.00) in n-back task compare to their performance before the tDCS sessions. Subjects didn’t show significant difference through the same analysis which was performed in the control group. Conclusion: According to the n-back task results, before and after tDCS 3-session intervention, anodal transcranial stimulation on dorsal-lateral prefrontal cortex (DLPFC) improves the performance of healthy subjects in the experimental group and tDCS neuromodulation could be an alternative way to improve cognition abilities like working memory among of healthy people.
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