کاربرد آیروژل ها در زخم پوش ها
محورهای موضوعی : پليمرها و نانوفناوریمحمدحسین کرمی 1 , علی زمانیان 2
1 - پژوهشکده فناوری نانو و مواد پیشرفته، پژوهشگاه مواد و انرژی، کرج، ایران
2 - پژوهشکده فناوری نانو و مواد پیشرفته، پژوهشگاه مواد و انرژی، کرج، ایران
کلید واژه: آیروژل, زخم پوش, ضد باکتری, کیتوسان, کامپوزیت,
چکیده مقاله :
آیروژل ها مواد جامد سبک وزنی هستند که از مواد آلی یا معدنی یا به صورت کامپوزیت تهیه می شوند و به عنوان مواد پیشرفته برای کاربردهای مختلف مورد بررسی قرار می گیرند. استفاده از آیروژل ها، در کاربردهای روزانه به دلیل هزینه بالا و روش پیچیده تهیه آنها محدود است. روش خشک کردن آیروژل ها به خودی خود یک کار خسته کننده است که نیاز به انرژی و منابع بالایی دارد. آیروژل ها هنگامی که به عنوان کامپوزیت تهیه می شوند می توانند خواص مکانیکی را به طور هم افزایی افزایش دهند. علاوه بر این، آیروژل‌ها را می‌توان به راحتی برای آزادسازی مولکول‌های فعال زیستی، مانند فاکتورهای رشد یا آنتی‌بیوتیک‌ها، برای تسریع روند بهبودی طراحی کرد. با این حال، چالش‌های مرتبط با استفاده از آیروژل در کاربردهای ترمیم زخم نیز وجود دارد. به عنوان مثال، تولید آیروژل ها در مقیاس بزرگ ممکن است گران باشد، که ممکن است پذیرش گسترده آنها را در محیط های بالینی محدود کند. علاوه بر این، خواص مکانیکی آیروژل‌ها ممکن است برای همه انواع زخم‌ها مناسب نباشد، زیرا ممکن است پشتیبانی کافی برای انواع خاصی از زخم‌ها ارایه نکنند. به طور کلی، در حالی که آیروژل‌ها برای کاربردهای ترمیم زخم پوش اهمیت زیادی دارند، تحقیقات بیشتری برای غلبه بر این چالش‌ها و بهینه‌سازی استفاده از آنها در محیط‌های بالینی مورد نیاز است. در این پژوهش، به بررسی معرفی انواع زخم پوش ها، زخم پوش های تجاری، آیروژل های پایه کیتوسان، خواص و کاربرد آیروژل ها در زخم پوش ها پرداخته می شود.
Aerogels are lightweight solid materials that are made from organic or inorganic materials, or as composites, and are being studied as advanced materials for various applications. The use of aerogels in everyday applications is limited due to their high cost and complex preparation process. Drying aerogels can be laborious, requiring significant energy and resources. When prepared as composites, aerogels can enhance mechanical properties. They can also be tailored to release bioactive molecules, such as growth factors or antibiotics, to speed up the healing process. However, there are challenges in using aerogels for wound healing. Large-scale production may be costly, limiting their use in clinical settings. Additionally, the mechanical properties of aerogels may not be suitable for all wound types. Further research is needed to overcome these challenges and optimize the use of aerogels in clinical settings. This research investigates different types of wound dressings, commercial wound dressings, chitosan-based aerogels, and the properties and applications of aerogels in wound dressings. The unique properties of aerogels, such as their high porosity, large surface area, and biocompatibility, make them ideal candidates for enhancing the wound healing process. Studies have shown that aerogels made from chitosan can improve cell adhesion, proliferation, and migration, resulting in quicker and more efficient wound closure. Furthermore, the controlled release of bioactive molecules from aerogels can further improve the healing process by reducing inflammation and promoting tissue regeneration.
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