The Effect of Resistance Training on The Changes in Serum Angiogenesis Stimulating Factors and The Progression of Retinopathy in Diabetic Patients
محورهای موضوعی : فیزیولوژی ورزشی
Alireza Babaei Mazreno
1
,
Ismail Babaei
2
1 - Department of Sport Sciences, Islamic Azad University of Isfahan, Khorasgan Branch, Isfahan, Iran.
2 - Retina specialist, Faculty of Sadoughi University of Medical Sciences, Yazd, Iran.
کلید واژه: VEGF and NO, Endurance training, Retinopathy, Type 2 diabetes,
چکیده مقاله :
Background: Diabetic retinopathy is one of the most serious complications of Retina microvascular disorder, so the aim of this study was to investigate the effect of resistance training on changes in serum regressive stimulating factors and retinopathy progression in diabetic patients.
Materials and Methods: 24 men with type 2 diabetes without retinopathy symptoms were selected purposefully and randomly divided into two groups of 12 experimental controls. The experimental group performed 6 months of resistance training, three sessions per week with 65% intensity and 5% overload after all 6 sessions. Before and after 6 months, growth factor concentrations of vascular endothelium, nitric oxide and fasting blood sugar were measured and recorded, and finally the data were analyzed using correlated t-test, independent t and chi square. The meaning level was less than 0.05.
Results: Comparison of pre-test and post-test changes between the control and experimental groups showed that no (P=.001) and VEGF (P=.001) of the subjects after 6 months of resistance training had a significant difference with the control group, but there was no significant difference between the control and experimental groups.
Conclusion: A period of resistance training can increase growth factor derived from endothelium and plasma nitric oxide in diabetic patients and it may be hypothesized that exercise, in addition to controlling diabetes through increasing these factors, may also be effective in preventing retinopathy.
Background: Diabetic retinopathy is one of the most serious complications of Retina microvascular disorder, so the aim of this study was to investigate the effect of resistance training on changes in serum regressive stimulating factors and retinopathy progression in diabetic patients.
Materials and Methods: 24 men with type 2 diabetes without retinopathy symptoms were selected purposefully and randomly divided into two groups of 12 experimental controls. The experimental group performed 6 months of resistance training, three sessions per week with 65% intensity and 5% overload after all 6 sessions. Before and after 6 months, growth factor concentrations of vascular endothelium, nitric oxide and fasting blood sugar were measured and recorded, and finally the data were analyzed using correlated t-test, independent t and chi square. The meaning level was less than 0.05.
Results: Comparison of pre-test and post-test changes between the control and experimental groups showed that no (P=.001) and VEGF (P=.001) of the subjects after 6 months of resistance training had a significant difference with the control group, but there was no significant difference between the control and experimental groups.
Conclusion: A period of resistance training can increase growth factor derived from endothelium and plasma nitric oxide in diabetic patients and it may be hypothesized that exercise, in addition to controlling diabetes through increasing these factors, may also be effective in preventing retinopathy.
1. Riyahi Malayeri S, Azadniya A, Rasaee M J. Effect of eight-week High intensity interval training nd resveratrol intake on serum adiponectin and resistin in type 2 diabetic rats. Ijdld 2019; 18 (1) :8-1. URL: http://ijdld.tums.ac.ir/article-1-5708-en.html.
2. Chen W, Balland E, Cowley MA. Hypothalamic Insulin Resistance in Obesity: Effects on Glucose Homeostasis. Neuroendocrinology. 2017;104(4):364-381. doi: 10.1159/000455865. Epub 2017 Jan 26. PMID: 28122381.
3. Mujeeb Rahman KK, Nasor M, Imran A. Automatic Screening of Diabetic Retinopathy Using Fundus Images and Machine Learning Algorithms. Diagnostics (Basel). 2022 Sep 19;12(9):2262. doi: 10.3390/diagnostics12092262. PMID: 36140666; PMCID: PMC9497622.
4. Jamurtas AZ, Stavropoulos-Kalinoglou A, Koutsias S, Koutedakis Y, Fatouros I. Adiponectin, Resistin, and Visfatin in Childhood Obesity and Exercise. Pediatr Exerc Sci. 2015 Nov;27(4):454-62. doi: 10.1123/pes.2014-0072. Epub 2015 Apr 22. PMID: 25902558.
5. Savikj M, Gabriel BM, Alm PS, Smith J, Caidahl K, Björnholm M, Fritz T, Krook A, Zierath JR, Wallberg-Henriksson H. Afternoon exercise is more efficacious than morning exercise at improving blood glucose levels in individuals with type 2 diabetes: a randomised crossover trial. Diabetologia. 2019 Feb;62(2):233-237. doi: 10.1007/s00125-018-4767-z. Epub 2018 Nov 13. PMID: 30426166; PMCID: PMC6323076.
6. Behjati A, Babai Mazrae No A, Faramarzi M. The Effect of Resistance Training on Vascular Endothelial Growth Factor (VEGF) in Older Women. Salmand: Iranian Journal of Ageing 2015; 10 (3) :156-165.
7. Fathollahi shoorabeh F L, Faramarzi M, Hemmati R L, Nuri R. The Effects of Ten Weeks Resistance Training on Resting Levels of Some Angiogenesis Factors Among Men with Prostate Cancer. yafte 2017; 19 (4) :129-139.
8. Röhling M., C. Herder, T. Stemper, and K. Müssig, “Influence of acute and chronic exercise on glucose uptake,” Journal Diabetes Research, vol. 2016, article 2868652, pp. 1–33, 2016.
9. Chung YR, Park SW, Choi SY, Kim SW, Moon KY, Kim JH, Lee K. Association of statin use and hypertriglyceridemia with diabetic macular edema in patients with type 2 diabetes and diabetic retinopathy. Cardiovasc Diabetol. 2017 Jan 7;16(1):4. doi: 10.1186/s12933-016-0486-2. PMID: 28061854; PMCID: PMC5219811.
10. Gong Q, Zhang P, Wang J, Ma J, An Y, Chen Y, Zhang B, Feng X, Li H, Chen X, Cheng YJ, Gregg EW, Hu Y, Bennett PH, Li G; Da Qing Diabetes Prevention Study Group. Morbidity and mortality after lifestyle intervention for people with impaired glucose tolerance: 30-year results of the Da Qing Diabetes Prevention Outcome Study. Lancet Diabetes Endocrinol. 2019 Jun;7(6):452-461. doi: 10.1016/S2213-8587(19)30093-2. Epub 2019 Apr 26. PMID: 31036503; PMCID: PMC8172050.
11. TaheriChadorneshin H, Ranjbar K, Nourshahi M. A Review of Response of Angiogenic and Angiostatic Factors to Exercise. Intern Med Today 2017; 23 (4) :331-338.
12. Mehri Alvar Y, Sayevand Z, Erfani Adab. F, Heydari Moghadam R, Samavat Sharif MA, Karami S. The effects of five weeks’ resistance training on some vascular growth factors in sedentary men. Sport Physiol.2016;8(29):15-30. [Persian].
13. Praidou A1, Harris M2, Niakas D3, Labiris G4.2017. Physical activity and its correlation to diabetic retinopathy. J Diabetes Complications. 2017 Feb;31(2):456-461. doi: 10.1016/j.jdiacomp.2016.06.027. Epub 2016 Jun 29.
14. Ren C, Liu W, Li J, Cao Y, Xu J, Lu P. Physical activity and risk of diabetic retinopathy: a systematic review and meta-analysis. Acta Diabetol. 2019 Aug;56(8):823-837. doi: 10.1007/s00592-019-01319-4. Epub 2019 Mar 21. PMID: 30900027.
15. Mohammad Shamsul Ola Haseeb A. Khan Abdullah S. Alhomida.2015. Role of Diet and Exercise in Diabetic Retinopathy.2015. Diet and Exercise in Cognitive Function and Neurological Diseases.
16. Tolouei Azar J, Ravasi A, Soori R, Akbarnejad A, Hemati Nafar M. The Effect of 8 Weeks Aerobic Training on Angiogenesis (VEGF) and Angiostatic (ES) Factors In Sedentary Women. Studies in Medical Sciences 2017; 27 (12) :1032-1040.
17. Vizvari E, Farzanegi P, Abbas Zade Sourati H. Effect of Vigorous Aerobic Training on Serum Levels of Some Inhibitory and Excitatory Factors of Angiogenesis in Women with Type 2 Diabetes. mjms 2018; 21 (3) :125-131.
18. Mohammadi1Reza, Fathei Mehrdad * 2, Hejazi3Keyvan. Effect of Eight-Weeks Aerobic Training on Serum Levels of Nitric Oxide and Endothelin-1 in Overweight Elderly Men. Salmand: Iranian Journal of Ageing 2018, 13(1): 74-85.
19. Psoma O, Makris M, Tselepis A, Tsimihodimos V. Short-term Glycemic Variability and Its Association With Macrovascular and Microvascular Complications in Patients With Diabetes. J Diabetes Sci Technol. 2024 Jul;18(4):956-967. doi: 10.1177/19322968221146808. Epub 2022 Dec 28. PMID: 36576014; PMCID: PMC11307209.
20. Yau JW, Rogers SL, Kawasaki R, Lamoureux EL, Kowalski JW, Bek T, Chen SJ, Dekker JM, Fletcher A, Grauslund J, Haffner S, Hamman RF, Ikram MK, Kayama T, Klein BE, Klein R, Krishnaiah S, Mayurasakorn K, O'Hare JP, Orchard TJ, Porta M, Rema M, Roy MS, Sharma T, Shaw J, Taylor H, Tielsch JM, Varma R, Wang JJ, Wang N, West S, Xu L, Yasuda M, Zhang X, Mitchell P, Wong TY; Meta-Analysis for Eye Disease (META-EYE) Study Group. Global prevalence and major risk factors of diabetic retinopathy. Diabetes Care. 2012 Mar;35(3):556-64. doi: 10.2337/dc11-1909. Epub 2012 Feb 1. PMID: 22301125; PMCID: PMC3322721.
21. Van Craenenbroeck EM, Vrints CJ, Haine SE, Vermeulen K, Goovaerts I, Van Tendeloo VF, Hoymans VY, Conraads VM. A maximal exercise bout increases the number of circulating CD34+/KDR+ endothelial progenitor cells in healthy subjects. Relation with lipid profile. J Appl Physiol (1985). 2008 Apr;104(4):1006-13. doi: 10.1152/japplphysiol.01210.2007. Epub 2008 Jan 24.
22. Arabzadeh E, Shirvani H, Ebadi Zahmatkesh M, Riyahi Malayeri S, Meftahi GH, Rostamkhani F. Irisin/FNDC5 influences myogenic markers on skeletal muscle following high and moderate-intensity exercise training in STZ-diabetic rats. 3 Biotech. 2022 Sep;12(9):193. doi: 10.1007/s13205-022-03253-9. Epub 2022 Jul 26. PMID: 35910290; PMCID: PMC9325938.
23. Riyahi Malayeri, S., Nikbakht, H, Gaeini (2014). Serum Chemerin Levels and Insulin Resistance Response to High- Intensity Interval Training in Overweight Men. Bulletin of Environment, Pharmacology and Life Sciences, 3(2), pp. 385-389.
24. Hosseini M, Ghasem Zadeh Khorasani N, Divkan B, Riyahi Malayeri S. Interactive Effect of High Intensity Interval Training with Vitamin E Consumption on the Serum Levels of Hsp70 and SOD in Male Wistar Rats. Iranian J Nutr Sci Food Technol 2019; 13 (4) :21-28URL: http://nsft.sbmu.ac.ir/article-1-2689-en.html.
