List of Articles Inflammation

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  1 - Inflammation role in wound management
  Mohsen Vahar Nasim Ghasemi
  The inflammatory phase is the body´s natural response to injury. After initial wounding, the blood vessels contract and a clot is formed. Followed by hemostasis has been achieved, blood vessels then dilated to allow essential cells, antibodies, white blood cells, growth More

  The inflammatory phase is the body´s natural response to injury. After initial wounding, the blood vessels contract and a clot is formed. Followed by hemostasis has been achieved, blood vessels then dilated to allow essential cells, antibodies, white blood cells, growth factors, enzymes and nutrients to reach the wound area. Erythema, heat, edema, pain and functional disturbance are the characteristic signs of inflammation that seen at this stage. The duration of the inflammatory phase usually lasts several days. Manuscript profile
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  2 - Pathophysiology of wound healing
  Hossein Gholami Behran Zamani Rad Saeed Farzad-Mohajeri
  Wound healing is an important concern in clinical medicine. Wound healing including skin wounds is a dynamic complicated procedure which involves many different molecular and cellular agents that occur after a tissue lesion in order to repair the injured tissue. Poor wo More

  Wound healing is an important concern in clinical medicine. Wound healing including skin wounds is a dynamic complicated procedure which involves many different molecular and cellular agents that occur after a tissue lesion in order to repair the injured tissue. Poor wound healing after trauma, surgery, or chronic disease such as diabetes affects human and animal life. Well understanding this process is necessary for developing therapeutic strategies and wound management to help treatment of normal healing procedure. The repair of wounded skin is included hemostasis and inflammation, proliferation, and maturation and remodeling. These steps have considerable overlaps with each other. Manuscript profile
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  3 - The effect of 12 weeks aerobic training on TNF-α levels in the hippocampus and prefrontal cortex, and depression in rats with Alzheimer's disease
  Ehsan Mohammadikia Fereshteh Mohebbi Hossein Babaei
  10.61186/jspac.37976.2.4.48
  Background: Exercise training plays an important role in combating Alzheimer's disease. Present study aimed to investigate the effect of 12 weeks aerobic training on the levels of tumor necrosis factor alpha (TNF-α) in the hippocampus and prefrontal cortex, and also dep More

  Background: Exercise training plays an important role in combating Alzheimer's disease. Present study aimed to investigate the effect of 12 weeks aerobic training on the levels of tumor necrosis factor alpha (TNF-α) in the hippocampus and prefrontal cortex, and also depression in rats with Alzheimer's disease. Methods: The 40 Wistar rats were divided into four equal groups including saline (S), saline +training (ST), training +STZ (AT) and STZ (A). Alzheimer's was induced by injection of 3 mg/kg streptozotocin (STZ) into the ventricles of brain. The aerobic training program (each session lasted 30 minutes with 10-12 meters per minute speed) performed for 12 weeks and five sessions per week on a treadmill. The 48 hours after last training session, brain tissue (hippocampal and prefrontal cortex areas) was removed and TNF-α levels were measured by ELISA method. Data were evaluated using the statistical method of analysis of variance at a significant level (P <0.05). Result: TNF-α levels in the hippocampus were significantly higher in group A compared to S (p= 0.010), ST (p= 0.014) and AT (p= 0.041) groups. Moreover, no significant change was observed for TNF-α levels in prefrontal cortex in different groups (p= 0.276). In addition, a significant increase in inactivity duration (FST) was observed in group A compared to other groups (p <0.05) and also a significant decrease in sucrose preference (SPT) was observed in group A compared to other groups. (p<0.05). Conclusion: The present study findings indicated that, the positive effects of aerobic training in rats with Alzheimer's disease are exerted partly by modulating the levels of inflammatory factors such as TNF-α in the brain especially the hippocampus. Manuscript profile