A review of polymer 3D printing technology: materials, process and design strategies for medical applications
Subject Areas :
1 - aut university
Keywords: 3D printing, polymers, mesh technology, engineering, medical,
Abstract :
چكيده انگليسي Polymer 3D printing is an emerging technology that further research in this field will lead to continuous improvement of polymer 3D printing design performance, which is necessary to push the boundaries in engineering and medicine. Polymer 3D printing provides the possibility of printing low-cost functional parts with various properties and capabilities. Here, by reviewing research on materials, processes and related strategies applied for medical applications, it is presented. Research in materials has led to the development of polymers with useful properties for mechanics and biocompatibility, by tuning the mechanical properties achieved by changing the parameters of the printing process. Polymer 3D printing technologies include extrusion, sheet lamination, Vat photo polymerization, additive layer, powder-based fusion, material projection, direct energy deposition. Thermal and laser inkjet techniques are more common. The two technologies of sheet exfoliation and direct energy deposition have limited medical applications. Which enables the direct deposition of design materials for useful and customized architectures. Design strategies, such as the hierarchical distribution of materials, make it possible to balance contrasting properties. The most investigated medical applications include tissue scaffolds, dental implants, medical education, delivery systems, and drug safety devices. And finally, the challenges and obstacles of polymer 3D printing were studied.
[1] Egan, P.F.; Bauer, I.; Shea, K.; Ferguson, S.J. Mechanics of Three-Dimensional Printed Lattices for Biomedical Devices. J. Mech. Des, 141, 031703, 2019.
[2] Provenzano, D.; Rao, Y.J.; Mitic, K.; Obaid, S.N.; Pierce, D.; Huckenpahler, J.; Berger, J.; Goyal, S.; Loew, M.H. Rapid Prototyping of Reusable 3D-Printed N95 Equivalent Respirators at the George Washington University, 2020030444. 2020.
[3] Moniruzzaman, M.; O’Neal, C.; Bhuiyan, A.; Egan, P.F. Design and Mechanical Testing of 3D Printed Hierarchical Lattices Using Biocompatible Stereolithography, 4, 22. 2020.
[4] Arabnejad, S.; Johnston, R.B.; Pura, J.A.; Singh, B.; Tanzer, M.; Pasini, D. High-strength porous biomaterials for bone replacement: A strategy to assess the interplay between cell morphology, mechanical properties, bone ingrowth and manufacturing constraints. Acta Biomater, 30, 345–356. 2016.
[5] Wang X, Ao Q, Tian X, et al. 3D bioprinting technologies for hard tissue and organ engineering. Materials; 9, 802. 2016.
[6] Gross B.C, Erkal J.L, Lockwood S.Y, Chen C, Spenc e D.M. Evaluation of 3D Printing and its Potential Impact on Biotechnology and the Chemical Sciences. ACS Publications; 2014.
[7] Xu Y, Wu X, Guo X, et al. The boom in 3D-printed sensor technology. Sensors; 17, 1166. 2017.
[8] Alifui-Segbaya, F.; Varma, S.; Lieschke, G.J.; George, R. Biocompatibility of Photopolymers in 3D Printing. 3d Print. Addit. Manuf, 4, 185–191. 2017.
[9] Miller, A.T.; Safranski, D.L.; Wood, C.; Guldberg, R.E.; Gall, K. Deformation and fatigue of tough 3D printed elastomer scaffolds processed by fused deposition modeling and continuous liquid interface production. J. Mech. Behav. Biomed. Mater, 75, 1–13. 2017.
[10] Nuseir, A.; Hatamleh, M.M.d.; Alnazzawi, A.; Al-Rabab’ah, M.; Kamel, B.; Jaradat, E. Direct 3D printing of flexible nasal prosthesis: Optimized digital workflow from scan to fit. J. Prosthodont, 28, 10–14. 2019.
[11] Egan, P.; Wang, X.; Greutert, H.; Shea, K.; Wuertz-Kozak, K.; Ferguson, S. Mechanical and biological characterization of 3D printed lattices. 3d Print. Addit. Manuf, 6, 73–81. 2019.
[12] Crump, M.R.; Bidinger, S.L.; Pavinatto, F.J.; Gong, A.T.; Sweet, R.M.; MacKenzie, J.D. Sensorized tissue analogues enabled by a 3D-printed conductive organogel. Npj Flex. Electron, 5, 1–8. 2021.
[13] ACFoAM Technologies, ACFoAMTSFo Terminology. Standard Terminology for Additive Manufacturing Technologies. ASTM International; 2012.
[14] Liaw C.-Y, Guvendiren M. Current and emerging applications of 3D printing in medicine. Biofabrication; 9:024102. 2017.
[15] Ikuta K, Hirowatari K. Real three dimensional micro fabrication using stereo lithography and metal molding, Micro Electro Mechanical Systems. In: MEMS’93, Proceedings an Investigation of Micro Structures, Sensors, Actuators, Machines and Systems IEEE. IEEE1993, 42–47. 1993.
[16] Bhatt acharjee N, Urrios A, Kang S, Folch A. The upcoming 3D-printing revolution in microfluidics. Lab a Chip; 16, 1720–1742. 2016.
[17] Kumar S. Selective laser sintering: a qualitative and objective approach. JOM (J Occup Med); 55, 43–47. 2003.
[18] Kruth J.-P, Mercelis P, Van Vaerenbergh J, Froyen L, Rombouts M. Binding mechanisms in selective laser sintering and selective laser melting. Rapid Prototyping J; 11, 26–36. 2005.
[19] Waheed S, Cabot J.M, Macdonald N.P, et al. 3D printed microfluidic devices: enablers and barriers. Lab a Chip; 16, 1993–2013. 2016.
[20] Pilipović A, Raos P, Šercer M. Experimental analysis of properties of materials for rapid prototyping. Int J Adv Manuf Technol; 40, 105–115. 2009.
[21] Provaggi E, Kalaskar D.M. 3D printing families: laser, powder, nozzle based techniques. 3D Print Med; 21–42, 2017.
[22] Murphy S.V, Atala A. 3D bioprinting of tissues and organs. Nat Biotechnol; 32, 773. 2014.
[23] Park J, Tari M.J, Hahn H.T. Characterization of the laminated object manufacturing (LOM) process. Rapid Prototyp J; 6, 36–50. 2000.
[24] Mueller B, Kochan D. Laminated object manufacturing for rapid tooling and pa ern making in foundry industry. Comput Ind; 39, 47–53. 1999.
[25] Horn T.J, Harrysson O.L. Overview of current additive manufacturing technologies and selected applications. Sci Prog; 95, 255–282. 2012.
[26] Thompson S.M, Bian L, Shamsaei N, Yadollahi A. A n overview of Direct Laser Deposition for additive manufacturing; part I: transport phenomena, modeling and diagnostics. Additive Manufacturing; 8, 36–62. 2015.
[27] Egan, P.F.; Gonella, V.C.; Engensperger, M.; Ferguson, S.J.; Shea, K. Computationally designed lattices with tuned properties for tissue engineering using 3D printing, 12, e0182902. 2017.
[28] Revilla-León, M.; Gonzalez-Martín, Ó.; Pérez López, J.; Sánchez-Rubio, J.L.; Özcan, M. Position accuracy of implant analogs on 3D printed polymer versus conventional dental stone casts measured using a coordinate measuring machine. J. Prosthodont, 27, 560–567. 2018.
[29] Zuniga, J.; Katsavelis, D.; Peck, J.; Stollberg, J.; Petrykowski, M.; Carson, A.; Fernandez, C. Cyborg beast: A low-cost 3d-printed prosthetic hand for children with upper-limb differences. BMC Res, 8, 10. 2015.
[30] Economidou, S.N.; Lamprou, D.A.; Douroumis, D. 3D printing applications for transdermal drug delivery. Int. J. Pharm, 544, 415–424. 2018.
[31] Rubio-Perez, I.; Diaz Lantada, A. Surgical Planning of Sacral Nerve Stimulation Procedure in Presence of Sacral Anomalies by Using Personalized Polymeric Prototypes Obtained with Additive Manufacturing Techniques. Polymers, 12, 581. 2020.
[32] Erickson, M.M.; Richardson, E.S.; Hernandez, N.M.; Bobbert, D.W., II; Gall, K.; Fearis, P. Helmet Modification to PPE with 3D Printing During the COVID-19 Pandemic at Duke University Medical Center: A Novel Technique. J. Arthroplast, 35, S23–S27. 2020.
[33] Hollister, S.J.; Flanagan, C.L.; Zopf, D.A.; Morrison, R.J.; Nasser, H.; Patel, J.J.; Ebramzadeh, E.; Sangiorgio, S.N.; Wheeler, M.B.; Green, G.E. Design control for clinical translation of 3D printed modular scaffolds. Ann. Biomed. Eng, 43, 774–786. 2015.
[34] Mai, H.N.; Lee, K.B.; Lee, D.H. Fit of interim crowns fabricated using photopolymer-jetting 3D printing. J. Prosthet. Dent, 118, 208–215. 2017.
[35] Swennen, G.R.J.; Pottel, L.; Haers, P.E. Custom-made 3D-printed face masks in case of pandemic crisis situations with a lack of commercially available FFP2/3 masks. Int. J. Oral. Maxillofac. Surg, 49, 673–677. 2020.
[36] Roopavath U.K, Kalaskar D.M. Introduction to 3D printing in medicine. 3D Print Med:1– 20 Elsevier, 2017.
[37] Ballard D.H, Trace A.P, Ali S, et al. Clinical applications of 3D printing: primer for radiologists. Acad Radiol; 25:52–65. 2018.
