Simulation of Pyramidal Cells Firing Types and Adjustment of Their Characteristics by Means of Transient Potassium Currents
Subject Areas : electrical and computer engineeringZ. Daneshparvar 1 , M. R. Daliri 2
1 - University of Science and Technology
2 - University of Science and Technology
Keywords: Neural response cell modeling dorsal cochlear neuron latency,
Abstract :
Pyramidal cells of the dorsal cochlear nucleus (DCN) represent firing types with different latencies. They incorporate two transient potassium currents namely Ikif and Ikis with fast and slow inactivation gatings, respectively. Transient potassium currents i.e. currents having both activation and inactivation gatings influence on the latency before firing. These currents cause different neural responses containing a regular firing, or a long latency before firing with or without a leading spike. In this paper, the firing behavior of DCN pyramidal cells is simulated first with a 3-variable conductance-based model. Next, mechanisms underlie neural responses of the model are analyzed by dynamical systems analysis methods. The model is a reduced version of Kanold and Manis model with 10 variables.
[1] J. A. Connor and C. Stevence, "Prediction of repetitive firing behaviour from voltage clamp data on an isolated neurone soma," J. of Physiology, vol. 213, no. 1, pp. 31-53, Feb. 1971.
[2] J. A. Connor, D. Walter, and R. McKown, "Neural repetitive firing, modifications of the Hodgkin-Huxley axon suggested by experimental results from crustacean axons," Biophysical J., vol. 18, no. 1, pp. 81-102, Apr. 1977.
[3] J. H. Byrne, "Quantitative aspects of ionic conductance mechanisms contributing to firing pattern of motor cells mediating inking behavior in Aplysia California," J. of Neurophysiology, vol. 43, no. 3, pp. 651-668, 1980.
[4] J. H. Byrne, "Analysis of ionic conductance mechanisms in motor cells mediating inking behavior in Aplysia Californica," J. of Neurophysiology, vol. 43, no. 3, pp. 630-650, 1980.
[5] M. E. Rush and J. Rinzel, "The potassium A- current, low firing rates, and rebound excitation in Hodgkin-Huxley models," Bull. Math. Biology, vol. 57, no. 3, pp. 899-929, Nov. 1995.
[6] D. Golomb et al., "Mechanisms of firing patterns in fast-spiking cortical interneurons," PLoS Comput. Biol., vol. 3, no. 8, pp. 1498-1512, 2007.
[7] X. J. Cao and D. Oertel, "The magnitudes of hyperpolarization-activated and low-voltage-activated potassium currents co-vary in neurons of the ventral cochlear nucleus," J. of Neurophysiology, vol. 106, no. 2, pp. 630-640, May 2011.
[8] R. M. Leao et al., "Diverse levels of an inwardly rectifying potassium conductance generate heterogeneous neuronal behavior in a population of dorsal cochlear nucleus pyramidal neurons," J. of Neurophysiology, vol. 107, no. 11, pp. 3008-3019, Jun. 2012.
[9] B. Rudy, "Diversity and ubiquity of K channels," Neuroscience, vol. 25, no. 3, pp. 729-749, Jun. 1988.
[10] B. Rudy et al., "Voltage gated potassium channels: structure and function of Kv1 to Kv9 subfamilies," Encyclopedia of Neuroscience, vol. 10, no. ???, pp. 397-425, ???. 2009.
[11] P. Deng et al., "Up-regulation of A- type potassium currents protects neurons against cerebral ischemia," J. of Cerebral Blood Flow & Metabolism, vol. 31, no. 9, pp. 1823-1835, Sep. 2011.
[12] J. Rothman and P. B. Manis, "The roles potassium currents play in regulating the electrical activity of ventral cochlear nucleus neurons," J. of Neurophysiology, vol. 89, no. 6, pp. 3097-3113, Jun. 2003.
[13] X. Meng, Q. Lu, and J. Rinzel, "Control of firing patterns by two transient potassium currents: leading spike, latency, and bistability," J. Compu.t Neurosc., vol. 31, no. 1, pp. 117-136, Aug. 2010.
[14] J. F. Storm, "Temporal integration by a slowly inactivating K+ current in hippocampal neurons," Nature, vol. 336, pp. 379-381, 24 Nov. 1988.
[15] P. O. Kanold and P. B. Manis, "A physiologically based model of discharge pattern regulation by transient K+ currents in cochlear nucleus pyramidal cells," J. of Neurophysiology, vol. 85, no. 2, pp. 523-538, Feb. 2001.
[16] W. S. Rhode, P. H. Smith, and D. Oertel, "Physiological response properties of cells labeled intracellularly with horseradish peroxidase in cat dorsal cochlear nucleus," J. of Comparative Neurology, vol. 213, no. 14, pp. 426-447, 1 Feb. 1983.