Background: This study aimed to investigate the effect of coenzyme Q10 consumption for fourteen days on the response of some indicators of oxidative stress and muscle damage following two consecutive football matches in college players Materials and Methods: for this purpose, 24 football players (with an average age of 20.08±12.1 years, a weight of 63.28±65.1 kg and a maximum oxygen consumption of 53.12± 0.98 ml /per /kg of body weight) The three groups were studied over a fourteen-day period. The control group did not receive these supplements and exercise activities, but the experimental groups included the placebo group (300 mg aspartame) and the coenzyme Q10 group (300 mg ubiquinone supplement) during the course in addition to receiving a placebo or supplement the two 90-minute football matches were less than 48 hours apart. Then, according to the research plan, blood samples were collected from the subjects in two stages 24 hours before and after the period and MDA, LDH, CK and AST indices were measured. Dependent t-test, one-way analysis of variance and Tukey's post hoc test were also used. Results: The results showed a significant difference between serum coenzyme Q 10 supplementation with serum MDA (P = 0.000) and AST (P = 0.006) concentrations from two consecutive football matches, while LDH levels (P = 0.970) and serum CK (P = 0.911) did not change significantly. Conclusion: Overall, the results show that supplementing coenzyme Q10 before and during a two-week match can have anti-oxidant benefits, so it can be recommended to college soccer players. تفاصيل المقالة

According to the investigation, Lipokines are a kind of bioactive compounds, derived from adipose tissue deposition, which manages multiple molecular signaling pathways. In recent years, 12,13-dihydroxy-9Z-octadecanoic acid (12,13-diHOME), an Oxylipin, has become increasingly important in the scientific literature. An increase of 12,13-diHOME in circulation was associated with an improvement in metabolic health, and the action of this molecule seems to be mediated by brown adipose tissue (BAT)(1). In fact, Oxylipins are oxidized metabolites of long-chain polyunsaturated fatty acids (PUFAs). PUFAs may be received immediately from the weight loss program or from the metabolism of linoleic acid and α-linolenic acid(2). Research indicates that Oxylipins are present in every tissue, urine and blood(3). Linoleic acid may be metabolized through cytochrome P450 (CYP) in order to produce 12,13-diHOME(4). Circulating concentrations of BATokine 12,13-dihydroxy-9Z-octadecenoic (12,13-diHOME) in rodents and humans have been shown to be elevated following exposure to cold and exercise. In other words, in mice, administration of 12,13-diHOME increased fatty acid absorption by brown/beige adipocytes and skeletal muscle after a session of moderate-intensity training, and in rodents using the same training protocol. Furthermore, investigation suggests that circulating 12,13-diHOME is associated with an increase in mitochondrial respiration capacity in the skeletal muscle. This information improves the opportunity that will increase in circulating 12,13-diHOME with exercising capabilities to assist expand the respiratory capacity of a training skeletal muscle and might increase exercise potential(5,6). تفاصيل المقالة