بررسی رهایش نانوحامل‌های دارویی پایه کیتوسان در درمان تومورهای سرطانی
الموضوعات :محمدحسین کرمی 1 , مجید عبدوس 2 , ماندانا کرمی 3
1 - دانشکده شیمی، دانشگاه صنعتی امیر کبیر (پلی تکنیک تهران)
2 - دانشکده شیمی، دانشگاه صنعتی امیرکبیر ، تهران، صندوق پستی: 4413- 15875
3 - پژوهشگاه پلیمر و پتروشیمی، تهران، ایران، صندوق پستی: 112- 14975
الکلمات المفتاحية: نانوحامل, کیتوسان, سرطان, تومور, رهایش دارو,
ملخص المقالة :
سامانه‌های هدفمند رهایش دارو منجر به کاهش عوارض جانبی در بدن انسان می‌شوند و به‌دلیل افزایش نفوذپذیری، امکان تجمع بهتر داروها در محل تومور سرطانی را فراهم می‌کنند. سرعت رهاسازی آهسته برای کاربرد رهایش دارو مناسب است، زیرا میزان آسیب به سلول‌های طبیعی را کاهش می‌دهد و منجر به کاهش عوارض جانبی می‌شود. پیوند هیدروژنی در محیط بافت سالم، باعث افزایش پایداری می‌شود و همچنین ساخت نانوحامل دارویی به روش امولسیونی دوگانه باعث رهایش داروها به‌صورت آهسته می‌شود. استفاده از نانوذرات به‌عنوان حامل دارو نیز به‌دلیل قابلیت حمل دارو به قسمت‌های مختلف بدن در زمان مناسب، بسیار مهم است. استفاده از سامانه‌های دارورسانی بر پایه نانوذرات بارگذاری شده با عوامل ضدسرطان، روشی موثر برای هدف‌گذاری سلول‌های سرطانی است. این سامانه‌ها با قابلیت نفوذ بهتر در داخل سلول‌ها، دارو را به صورت هدفمند در سلول‌ها ترکیب می‌کنند. همچنین، به‌دلیل افزایش نفوذپذیری (EPR)، امکان تجمع بهتر داروها در محل تومور فراهم می‌شود. در سامانه‌های دارورسانی، افزایش رهایش در محیط سرطانی نسبت به سامانه‌های فیزیولوژیکی به‌عنوان مزیت برای کاهش سمیت بر روی بافت سالم در نظر گرفته می‌شود. در این پژوهش برای اولین بار، پروفایل رهایش نانوحامل‌های دارویی حاوی داروهای ضدسرطان بررسی شده است
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