The effects of detraining following a regular exercise program on plasma resistin concentrations in asthmatic patients
الموضوعات :
1 - Assistant Professor, Department of Physical Education & Sport Sciences, Faculty of Humanities, Parand Branch, Islamic Azad University, Parand, Tehran, Iran
الکلمات المفتاحية: Resistin, Regular Exercise, Asthmatics, Detraining,
ملخص المقالة :
Background: The purpose of this study was to investigate the effects of regular exercise and the following detraining on plasma resistin concentration in patients with asthma. Climate change and reduced rainfall have caused allergies and respiratory diseases to develop in different people, resulting in 8.9% of adults suffering from asthma by 2025, and 400 million by 2050. Asthma prevalence or symptoms increase as a result of the secretion of some adipokines, such as the hormone resistin. Detraining results when there is insufficient training stimulus, causing the loss of training-induced adaptations. Training cessation or insufficient training can alter the detraining characteristics. Materials and Methods: In the present study, 30 available asthmatics were randomly divided into control and exercise groups. For three months, the exercise group followed a regular training regimen that included three 90-minute sessions each week. Each training session included 60 to 85% of the patients' maximum heart rate on the treadmill or pedaling on an ergometer. The control group did not do any physical exercise in addition to their normal routines throughout the same time period. Blood samples were drawn before the first session, 2 days, and 1 month after the last sessions. Results: Serum resistin levels were not affected by the three-month regular training program or one-month detraining period. They did not differ significantly in the control group either (P >0.05). Conclusion: Despite the benefits of regular exercise being beneficial for all individuals, asthma symptoms in asthmatics were relatively reduced, although these changes were not significant.
1. He S, Lu Y, Li M. Probabilistic risk analysis for coal mine gas overrun based on FAHP and BN: a case study. Environ Sci Pollut Res Int. 2022 Apr;29(19):28458-28468. doi: 10.1007/s11356-021-18474-3. Epub 2022 Jan 6. PMID: 34993806.
2. Albano GD, Montalbano AM, Gagliardo R, Anzalone G, Profita M. Impact of Air Pollution in Airway Diseases: Role of the Epithelial Cells (Cell Models and Biomarkers). Int J Mol Sci. 2022 Mar 3;23(5):2799. doi: 10.3390/ijms23052799. PMID: 35269941; PMCID: PMC8911203.
3. Faraji M, Mohammadi A, Najmi M, Fallahnezhad M, Sabetkish N, Kazemnejad A, Shokouhi Shoormasti R, Fazlollahi MR, Pourpak Z, Moin M. Exposure to road noise and asthma prevalence in adults. Environ Sci Pollut Res Int. 2022 Apr;29(16):23512-23519. doi: 10.1007/s11356-021-17531-1. Epub 2021 Nov 22. PMID: 34806147.
4. Jabbarpour A. What percentage of Iranians have asthma? Tehran: Islamic Republic News Agency; 2021 [Available from: irna.ir/xjDJ4g.
5. Sabeti Z, Ansarin K, Seyedrezazadeh E, Asghari Jafarabadi M, Zafari V, Dastgiri S, et al. A comparison of asthma prevalence in adolescents living in urban and semi-urban areas in northwestern Iran. Human and Ecological Risk Assessment: An International Journal. 2021;27(8):2051-68.
6. Shakerkhatibi M, Benis KZ, Asghari-Jafarabadi M, et al. Air pollution-related asthma profiles among children/adolescents: A multi-group latent class analysis. Ecotoxicology and Environmental Safety. 2021 Aug;219:112344. DOI: 10.1016/j.ecoenv.2021.112344. PMID: 34023726.
7. Reddel HK, Bacharier LB, Bateman ED, Brightling CE, Brusselle GG, Buhl R, Cruz AA, Duijts L, Drazen JM, FitzGerald JM, Fleming LJ, Inoue H, Ko FW, Krishnan JA, Levy ML, Lin J, Mortimer K, Pitrez PM, Sheikh A, Yorgancioglu AA, Boulet LP. Global Initiative for Asthma Strategy 2021: Executive Summary and Rationale for Key Changes. Am J Respir Crit Care Med. 2022 Jan 1;205(1):17-35. doi: 10.1164/rccm.202109-2205PP. PMID: 34658302; PMCID: PMC8865583.
8. Motamedi M. Cities across Iran engulfed in thick layers of dust, pollutants: Al Jazeera Media Network; 2022 [Available from: https://www.aljazeera.com/news/2022/4/9/irans-capital-tehran-enveloped-by-pollutants-due-to-strong-wind.
9. Rahman MM, Islam MR, Shohag S, Hossain ME, Rahaman MS, Islam F, Ahmed M, Mitra S, Khandaker MU, Idris AM, Chidambaram K, Emran TB, Cavalu S. The Multifunctional Role of Herbal Products in the Management of Diabetes and Obesity: A Comprehensive Review. Molecules. 2022 Mar 6;27(5):1713. doi: 10.3390/molecules27051713. PMID: 35268815; PMCID: PMC8911649.
10. Laveti D, Kumar M, Hemalatha R, Sistla R, Naidu VG, Talla V, Verma V, Kaur N, Nagpal R. Anti-inflammatory treatments for chronic diseases: a review. Inflamm Allergy Drug Targets. 2013 Oct;12(5):349-61. doi: 10.2174/18715281113129990053. PMID: 23876224..
11. Sato E, Nelson DK, Koyama S, Hoyt JC, Robbins RA. Inflammatory cytokines modulate eotaxin release by human lung fibroblast cell line. Exp Lung Res. 2001 Mar;27(2):173-83. doi: 10.1080/019021401750069401. PMID: 11258804.
12. Tillie-Leblond I, Pugin J, Marquette CH, Lamblin C, Saulnier F, Brichet A, Wallaert B, Tonnel AB, Gosset P. Balance between proinflammatory cytokines and their inhibitors in bronchial lavage from patients with status asthmaticus. Am J Respir Crit Care Med. 1999 Feb;159(2):487-94. doi: 10.1164/ajrccm.159.2.9805115. PMID: 9927362.
13. Lin Q, Johns RA. Resistin family proteins in pulmonary diseases. Am J Physiol Lung Cell Mol Physiol. 2020 Sep 1;319(3):L422-L434. doi: 10.1152/ajplung.00040.2020. Epub 2020 Jun 17. PMID: 32692581; PMCID: PMC7518061.
14. Sood A, Shore SA. Adiponectin, Leptin, and Resistin in Asthma: Basic Mechanisms through Population Studies. J Allergy (Cairo). 2013;2013:785835. doi: 10.1155/2013/785835. Epub 2013 Oct 30. PMID: 24288549; PMCID: PMC3832971.
15. Abdolali Banaeifar; Sakine Taheri; Mehdi Nora; Mojtaba Izadi. "The Effect of Three Months of Aerobic Training on Serum Levels of Adiponectin and Resistin in Obese Men". Report of Health Care, 3, 1, 2017, 48-55.
16. Farzan S, Coyle T, Coscia G, Rebaza A, Santiago M. Clinical Characteristics and Management Strategies for Adult Obese Asthma Patients. J Asthma Allergy. 2022 May 18;15:673-689. doi: 10.2147/JAA.S285738. PMID: 35611328; PMCID: PMC9124473.
17. Shahgholi Abasi R, Izadi M, Soheili S, Imanzadeh R. Serum Resistin and Insulin Resistance Responses to Long-Term Physical Exercise in the Absence of Diet Control in Middle-Aged Obese Men. J Mazandaran Univ Med Sci. 2012; 21 (86) :126-130
URL: http://jmums.mazums.ac.ir/article-1-860-en.html
18. Lucas SR, Platts-Mills TA. Physical activity and exercise in asthma: relevance to etiology and treatment. J Allergy Clin Immunol. 2005 May;115(5):928-34. doi: 10.1016/j.jaci.2005.01.033. Erratum in: J Allergy Clin Immunol. 2005 Aug;116(2):298. PMID: 15867847.
19. Czosnek L, Lederman O, Cormie P, Zopf E, Stubbs B, Rosenbaum S. Health benefits, safety and cost of physical activity interventions for mental health conditions: A meta-review to inform translation efforts. Mental Health and Physical Activity. 2019;16:140-51.
20. Calcaterra V, Verduci E, Ghezzi M, Cena H, Pascuzzi MC, Regalbuto C, Lamberti R, Rossi V, Manuelli M, Bosetti A, Zuccotti GV. Pediatric Obesity-Related Asthma: The Role of Nutrition and Nutrients in Prevention and Treatment. Nutrients. 2021 Oct 21;13(11):3708. doi: 10.3390/nu13113708. PMID: 34835964; PMCID: PMC8620690.
21. Oudjedi A, Aissa KS. Associations between obesity, asthma and physical activity in children and adolescents. Apunts Sports Medicine. 2020;55(205):39-48.
22. Shi S, Huang H, Zheng R, Zhang N, Dai W, Liang J, Dai Y. Can long-term regular physical activity improve health outcomes among adults with asthma-evidence from a systematic review and Bayesian meta-analysis. Ann Transl Med. 2022 Mar;10(6):338. doi: 10.21037/atm-22-1170. PMID: 35434043; PMCID: PMC9011288.
23. Kelly AS, Steinberger J, Olson TP, Dengel DR. In the absence of weight loss, exercise training does not improve adipokines or oxidative stress in overweight children. Metabolism. 2007 Jul;56(7):1005-9. doi: 10.1016/j.metabol.2007.03.009. PMID: 17570265.
24. Jamurtas AZ, Theocharis V, Koukoulis G, Stakias N, Fatouros IG, Kouretas D, Koutedakis Y. The effects of acute exercise on serum adiponectin and resistin levels and their relation to insulin sensitivity in overweight males. Eur J Appl Physiol. 2006 May;97(1):122-6. doi: 10.1007/s00421-006-0169-x. Epub 2006 Mar 9. PMID: 16525810.
25. Kim KW, Shin YH, Lee KE, Kim ES, Sohn MH, Kim KE. Relationship between adipokines and manifestations of childhood asthma. Pediatr Allergy Immunol. 2008 Sep;19(6):535-40. doi: 10.1111/j.1399-3038.2007.00690.x. Epub 2008 Jan 25. PMID: 18221467..
26. Larochelle J, Freiler J, Dice J, Hagan L. Plasma resistin levels in asthmatics as a marker of disease state. J Asthma. 2007 Sep;44(7):509-13. doi: 10.1080/02770900701495785. PMID: 17885852..
27. Tiotiu A, Labor M, Nedeva D, Novakova S, Oguzulgen IK, Mihaicuta S, Braido F. How to apply the personalized medicine in obesity-associated asthma? Expert Rev Respir Med. 2020 Sep;14(9):905-915. doi: 10.1080/17476348.2020.1780123. Epub 2020 Jul 7. PMID: 32506978.
28. AfshounPour M, Davoodi Z, Habibi H, Ranjbar R, Shakerian S. The Effect of Circuit Resistance Exercise On Plasma Resistin Concentration and Insulin Resistance in Type 2 Diabetic Men. JSSU. 2015; 23 (8) :770-781
URL: http://jssu.ssu.ac.ir/article-1-3230-en.html
29. Acquarone E, Monacelli F, Borghi R, Nencioni A, Odetti P. Resistin: A reappraisal. Mech Ageing Dev. 2019 Mar;178:46-63. doi: 10.1016/j.mad.2019.01.004. Epub 2019 Jan 14. PMID: 30650338.
30. Dehghani K, Mogharnasi M, Talei Rudy M. The Effect of High-intensity Interval Training (HIIT) on Plasma Levels of Resistin in Male Non-athlete Students (A Trial Study). Qom Univ Med Sci J. 2016; 9 (11) :33-40
URL: http://journal.muq.ac.ir/article-1-247-en.html
31. Jazi A, Gharehkhani M. The effect of aerobic exercise training on serum resistin levels and its relationship with insulin resistance in overweight elderly women. aspjournals. 2013;8(15):41-52.
32. Riyahi Malayeri S, Saei M. Changes in Insulin resistance and serum levels of resistin after 10 weeks high intensity interval training in overweight and obese men. Sport Physiology & Management Investigations. 2019;10(4):31-42.
33. Camiolo MJ, Kale SL, Oriss TB, Gauthier M, Ray A. Immune responses and exacerbations in severe asthma. Curr Opin Immunol. 2021 Oct;72:34-42. doi: 10.1016/j.coi.2021.03.004. Epub 2021 Mar 24. PMID: 33773471; PMCID: PMC8460694.
34. Li Y, Yang Q, Cai D, Guo H, Fang J, Cui H, Gou L, Deng J, Wang Z, Zuo Z. Resistin, a Novel Host Defense Peptide of Innate Immunity. Front Immunol. 2021 Jun 18;12:699807. doi: 10.3389/fimmu.2021.699807. PMID: 34220862; PMCID: PMC8253364.
35. Farbod M, Eizadi M, Rashidi M, Mirakhori Z. Effects of Aerobic Training With No Caloric Restriction on Serum Resistin and Lipid Profile in Inactive Overweight Women. International Journal of Basic Science in Medicine. 2020;5(1):9-15.
36. Kadoglou NP, Perrea D, Iliadis F, Angelopoulou N, Liapis C, Alevizos M. Exercise reduces resistin and inflammatory cytokines in patients with type 2 diabetes. Diabetes Care. 2007 Mar;30(3):719-21. doi: 10.2337/dc06-1149. PMID: 17327348.
37. Nakhaei H, Khalighi MRD, Mogharnasi M. The effects of ten-week training followed by four-week detraining on serum resistin of non-athlete iranian male students. Iioab Journal. 2016;7(10):7-11.
38. Lin C-C, Wang Y-P, Chen S-H, Hsu T-S, Ivy JL, Kuo C-H. Effect of Long-Term Detraining on Serum Resistin and Insulin Sensitivity in Athletes: 2425: Board# 8: May 31 9: 30 AM-11: 00 AM. Medicine & Science in Sports & Exercise. 2008;40(5):S456.
39. Bantulà M, Roca-Ferrer J, Arismendi E, Picado C. Asthma and Obesity: Two Diseases on the Rise and Bridged by Inflammation. J Clin Med. 2021 Jan 6;10(2):169. doi: 10.3390/jcm10020169. PMID: 33418879; PMCID: PMC7825135.
40. Litonjua AA, Gold DR. Asthma and obesity: common early-life influences in the inception of disease. J Allergy Clin Immunol. 2008 May;121(5):1075-84; quiz 1085-6. doi: 10.1016/j.jaci.2008.03.005. Epub 2008 Apr 18. PMID: 18378287.
