شبيهسازي الگوهاي شليک پتانسيل عمل نورونهاي هرمي و کنترل مشخصههاي آنها با استفاده از جريانهاي پتاسيمي گذرا
الموضوعات :زهرا دانشپرور 1 , محمدرضا دلیری 2
1 - دانشگاه علم و صنعت ايران
2 - دانشگاه علم و صنعت ايران
الکلمات المفتاحية: پاسخ نورونی مدلسازی سلولی هسته حلزونی پشتی (DCN) تأخیر پاسخ,
ملخص المقالة :
سلولهاي هرمي هسته حلزوني پشتي (DCN)، داراي الگوهاي پاسخ نوروني با تأخيرهاي متفاوتي هستند. اين سلولها داراي دو جريان پتاسيمي گذرا به نامهاي IKif و IKis هستند که بهترتيب داراي دريچههاي نافعال شوندگي با ديناميک سريع و آهسته ميباشند. جريان هاي پتاسيمي گذرا يعني جريانهاي داراي دريچههاي فعالشوندگي و نافعالشوندگي در تنظيم تأخير قبل از شليک پتانسيلهاي عمل تأثير دارند. اين جريانها الگوهاي متفاوتي از پاسخ نوروني مانند شليک پيوسته بلافاصله بعد از اعمال تحريک يا پاسخگويي با تأخيري طولاني بعد از ايجاد يک تک اسپايک پيشتاز يا حتي بدون تک اسپايک آغازين را به نمايش ميگذارند. در گزارش پيش رو، رفتار پاسخ نوروني سلولهاي هرمي DCN با استفاده از يک مدل دارای رسانایی 3متغيره شبيهسازي شده است و در ادامه با استفاده از روشهاي تحليلي سيستمهاي ديناميکي، مکانيسمهاي زيربنايي پاسخهاي نوروني مدل ارائهشده توجيه شده است. اين مدل نسخه کاهشيافتهاي از یک مدل الکتروفیزیولوژیکی با 10 متغير حالت میباشد.
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