The effect of 8 weeks of aerobic exercise and papaya supplementation on lipid profile of men with fatty liver in Yazd city
محورهای موضوعی : تغذیه ورزشی
leila Rahimi
1
,
Abbas Fattahi Bafghi
2
,
Seyed Abbas Hoseini Motlagh
3
1 - Department of Physical Education and Sports Sciences, Yazd Branch, Islamic Azad University, Yazd, Iran
2 - Department of Physical Education and Sports Sciences, Yazd Branch, Islamic Azad University, Yazd, Iran
3 - Department of Physical Education and Sports Sciences, Yazd Branch, Islamic Azad University, Yazd, Iran
کلید واژه: Aerobic exercise, fatty liver, papaya, lipid profile,
چکیده مقاله :
Background: Today, researches have shown that the combination of some herbal supplements and doing sports exercises can have more effects on the recovery of some diseases. Therefore, the purpose of this research is to investigate the effect of eight weeks of aerobic training and papaya supplement consumption on the lipid profile of men with fatty liver. Materials and Methods: The statistical population of the present study included all men with fatty liver in Yazd city, among whom there were 60 men with an average age of 25 to 35 years and a body mass index between 25 and 35 kg/m2, were randomly divided into four groups of 15 including aerobic exercise group, aerobic exercise group-papaya supplement, papaya supplement group and control group. The subjects of the training and training-supplementary group performed aerobic exercise according to the given program for eight weeks, three sessions per week and each session lasted for 70 minutes. In the same period, the supplement and training groups also received a papaya supplement in the form of capsules at a dose of 30 mg per kilogram of body weight every day after dinner. Karika Papaya Slim capsules produced in the Philippines in 2021 were prepared. Blood samples were taken from the subjects in the fasting state and at night, 72 hours before and after 8 weeks of training. Data analysis at the level of descriptive statistics using mean and standard deviation tests and at the level of inferential statistics after checking the normality of the data by the Shapiro-Wilk test. Two-way analysis of variance and Tukey's post hoc test were used. A significant level was considered in the current research (P<0.05) and all statistical steps were performed using spss25. Results: he present study showed that eight weeks of aerobic training with papaya supplementation had a significant effect on serum levels of low-density lipoprotein (LDL), high-density lipoprotein (HDL), and triglycerides (TG) However, there was no significant change in the level of cholesterol (TC) (P>0.05). Conclusion: Based on the results obtained from the present research, it is possible to use aerobic exercise and papaya supplement separately and especially simultaneously to improve the lipid profile of patients with fatty liver.
Background: Today, researches have shown that the combination of some herbal supplements and doing sports exercises can have more effects on the recovery of some diseases. Therefore, the purpose of this research is to investigate the effect of eight weeks of aerobic training and papaya supplement consumption on the lipid profile of men with fatty liver. Materials and Methods: The statistical population of the present study included all men with fatty liver in Yazd city, among whom there were 60 men with an average age of 25 to 35 years and a body mass index between 25 and 35 kg/m2, were randomly divided into four groups of 15 including aerobic exercise group, aerobic exercise group-papaya supplement, papaya supplement group and control group. The subjects of the training and training-supplementary group performed aerobic exercise according to the given program for eight weeks, three sessions per week and each session lasted for 70 minutes. In the same period, the supplement and training groups also received a papaya supplement in the form of capsules at a dose of 30 mg per kilogram of body weight every day after dinner. Karika Papaya Slim capsules produced in the Philippines in 2021 were prepared. Blood samples were taken from the subjects in the fasting state and at night, 72 hours before and after 8 weeks of training. Data analysis at the level of descriptive statistics using mean and standard deviation tests and at the level of inferential statistics after checking the normality of the data by the Shapiro-Wilk test. Two-way analysis of variance and Tukey's post hoc test were used. A significant level was considered in the current research (P<0.05) and all statistical steps were performed using spss25. Results: he present study showed that eight weeks of aerobic training with papaya supplementation had a significant effect on serum levels of low-density lipoprotein (LDL), high-density lipoprotein (HDL), and triglycerides (TG) However, there was no significant change in the level of cholesterol (TC) (P>0.05). Conclusion: Based on the results obtained from the present research, it is possible to use aerobic exercise and papaya supplement separately and especially simultaneously to improve the lipid profile of patients with fatty liver.
1. Farazandeh Nia, D., Hosseini, M., Riyahi Malayeri, S., Daneshjoo, A. Effect of Eight Weeks of Swimming Training with Garlic Intake on Serum Levels of IL-10 and TNF-α in Obese Male Rats. Jundishapur Scientific Medical Journal, 2018; 16(6): 665-671. doi: 10.22118/jsmj.2018.57830.
2. Riyahi Malayeri, S., Nikbakht, H, Gaeini (2014). Serum Chemerin Levels and Insulin Resistance Response to High- Intensity Interval Training in Overweight Men. Bulletin of Environment, Pharmacology and Life Sciences, 3(2), pp. 385-389.
3. Fon Tacer K, Rozman D. Nonalcoholic Fatty liver disease: focus on lipoprotein and lipid deregulation. J Lipids. 2011; 2011:783976. doi: 10.1155/2011/783976. Epub 2011 Jul 2. PMID: 21773052; PMCID: PMC3136146.
4. Chen Z, Hu H, Chen M, Luo X, Yao W, Liang Q, Yang F, Wang X. Association of Triglyceride to high-density lipoprotein cholesterol ratio and incident of diabetes mellitus: a secondary retrospective analysis based on a Chinese cohort study. Lipids Health Dis. 2020 Mar 4;19(1):33. doi: 10.1186/s12944-020-01213-x. PMID: 32131838; PMCID: PMC7057518.
5. Riyahi Malayeri, S., Mirakhorli, M. The Effect of 8 Weeks of Moderate Intensity Interval Training on Omentin Levels and Insulin Resistance Index in Obese Adolescent Girls. Sport Physiology & Management Investigations, 2018; 10(2):59-68. https://www.sportrc.ir/article_67070.html?lang=en .
6. Gohil KJ, Patel JA, Gajjar AK. Pharmacological Review on Centella asiatica: A Potential Herbal Cure-all. Indian J Pharm Sci. 2010 Sep;72(5):546-56. doi: 10.4103/0250-474X.78519. PMID: 21694984; PMCID: PMC3116297.
7. Singh SP, Kumar S, Mathan SV, Tomar MS, Singh RK, Verma PK, Kumar A, Kumar S, Singh RP, Acharya A. Therapeutic application of Carica papaya leaf extract in the management of human diseases. Daru. 2020 Dec;28(2):735-744. doi: 10.1007/s40199-020-00348-7. Epub 2020 May 5. PMID: 32367410; PMCID: PMC7704890.
Zinoubi B, Zbidi S, Vandewalle H, Chamari K, Driss T. Relationships between rating of perceived exertion, heart rate and blood lactate during continuous and alternated-intensity cycling exercises. Biol Sport. 2018 Mar;35(1):29-37. doi: 10.5114/biolsport.2018.70749. Epub 2017 Oct 12. PMID: 30237659; PMCID: PMC6135975.
9. Sharma A, Sharma R, Sharma M, Kumar M, Barbhai MD, Lorenzo JM, Sharma S, Samota MK, Atanassova M, Caruso G, Naushad M, Radha, Chandran D, Prakash P, Hasan M, Rais N, Dey A, Mahato DK, Dhumal S, Singh S, Senapathy M, Rajalingam S, Visvanathan M, Saleena LAK, Mekhemar M. Carica papaya L. Leaves: Deciphering Its Antioxidant Bioactives, Biological Activities, Innovative Products, and Safety Aspects. Oxid Med Cell Longev. 2022 Jun 9;2022:2451733. doi: 10.1155/2022/2451733. PMID: 35720184; PMCID: PMC9203216.
10. Riyahi Malayeri, S., Saei, M. Changes in Insulin resistance and serum levels of resistin after 10 weeks high intensity interval training in overweight and obese men. Sport Physiology & Management Investigations, 2019;10(4): 31-42.http://www.sportrc.ir/article_82662.html?lang=en.
11. Mohammadi, S., Rostamkhani, F., Riyahi Malayeri, S. et al. High-intensity interval training with probiotic supplementation decreases gene expression of NF-κβ and CXCL2 in small intestine of rats with steatosis. Sport Sci Health 18, 491–497 (2022). https://doi.org/10.1007/s11332-021-00829-5.
12. Mann S, Beedie C, Jimenez A. Differential effects of aerobic exercise, resistance training and combined exercise modalities on cholesterol and the lipid profile: review, synthesis and recommendations. Sports Med. 2014 Feb;44(2):211-21. doi: 10.1007/s40279-013-0110-5. PMID: 24174305; PMCID: PMC3906547.
13. Ademuyiwa OH, Fasogbon BM, Bamidele OP, Ukpo GE. Ameliorative effect of ethanolic extract of Carica papaya leaves on hyper-cholesterolemic rats: The egg yolk induced model. Heliyon. 2023 Jun 16;9(6):e17379. doi: 10.1016/j.heliyon.2023.e17379. PMID: 37441376; PMCID: PMC10333609.
14. Santana LF, do Espirito Santo BLS, Tatara MB, Negrão FJ, Croda J, Alves FM, de Oliveira Filiú WF, Cavalheiro LF, Nazário CED, Asato MA, de Faria BB, do Nascimento VA, de Cássia Avellaneda Guimarães R, de Cássia Freitas K, Hiane PA. Effects of the Seed Oil of Carica papaya Linn on Food Consumption, Adiposity, Metabolic and Inflammatory Profile of Mice Using Hyperlipidic Diet. Molecules. 2022 Oct 8;27(19):6705. doi: 10.3390/molecules27196705. PMID: 36235241; PMCID: PMC9570947.
15. shariatzadeh, M., Moghadam, Z., Maleki, L., Keshavarz, E., Hedayati, M. Short-Term Effect of Two Types of High-Intensity Interval Training on Plasma Level of TNF-α, IL-6, CRP and Lipid Profile of Overweight Women. Journal of Sport Biosciences, 2017 Sep 9(2):195-207. doi: 10.22059/jsb.2017.128575.963.
