Convolutional Neural Networks for Medical Image Segmentation and Classification: A Review
محورهای موضوعی : Image ProcessingJenifer S 1 , Carmel Mary Belinda M J 2
1 - School of Computing, VelTech Rangarajan Dr. Sagunthala R&D Institute of Science and Technology, Chennai, India
2 - School of Computing, VelTech Rangarajan Dr. Sagunthala R&D Institute of Science and Technology, Chennai, India
کلید واژه: Convolutional Neural Networks, Deep learning, Generative Adversarial Network, Medical Image Analysis, Transfer learning.,
چکیده مقاله :
Medical imaging refers to the process of obtaining images of internal organs for therapeutic purposes such as discovering or studying diseases. The primary objective of medical image analysis is to improve the efficacy of clinical research and treatment options. Deep learning has revamped medical image analysis, yielding excellent results in image processing tasks such as registration, segmentation, feature extraction, and classification. The prime motivations for this are the availability of computational resources and the resurgence of deep Convolutional Neural Networks. Deep learning techniques are good at observing hidden patterns in images and supporting clinicians in achieving diagnostic perfection. It has proven to be the most effective method for organ segmentation, cancer detection, disease categorization, and computer-assisted diagnosis. Many deep learning approaches have been published to analyze medical images for various diagnostic purposes. In this paper, we review the works exploiting current state-of-the-art deep learning approaches in medical image processing. We begin the survey by providing a synopsis of research works in medical imaging based on convolutional neural networks. Second, we discuss popular pre-trained models and General Adversarial Networks that aid in improving convolutional networks’ performance. Finally, to ease direct evaluation, we compile the performance metrics of deep learning models focusing on covid-19 detection and child bone age prediction.
Medical imaging refers to the process of obtaining images of internal organs for therapeutic purposes such as discovering or studying diseases. The primary objective of medical image analysis is to improve the efficacy of clinical research and treatment options. Deep learning has revamped medical image analysis, yielding excellent results in image processing tasks such as registration, segmentation, feature extraction, and classification. The prime motivations for this are the availability of computational resources and the resurgence of deep Convolutional Neural Networks. Deep learning techniques are good at observing hidden patterns in images and supporting clinicians in achieving diagnostic perfection. It has proven to be the most effective method for organ segmentation, cancer detection, disease categorization, and computer-assisted diagnosis. Many deep learning approaches have been published to analyze medical images for various diagnostic purposes. In this paper, we review the works exploiting current state-of-the-art deep learning approaches in medical image processing. We begin the survey by providing a synopsis of research works in medical imaging based on convolutional neural networks. Second, we discuss popular pre-trained models and General Adversarial Networks that aid in improving convolutional networks’ performance. Finally, to ease direct evaluation, we compile the performance metrics of deep learning models focusing on covid-19 detection and child bone age prediction.
[1] H. P. Chan, L. M. Hadjiiski, and R. K. Samala, “Computer-aided diagnosis in the era of deep learning,” Medical Physics, vol. 47, no. 5, pp. e218–e227, May 2020.
[2] F. Ritter, T. Boskamp, A. Homeyer, H. Laue, M. Schwier, F. Link, and H. O. Peitgen, “Medical Image Analysis,” IEEE Pulse, vol. 2, no. 6, pp. 60–70, Nov. 2011.
[3] J. Ker, L. Wang, J. Rao, and T. Lim, “Deep learning applications in medical image analysis,” IEEE Access, vol. 6, pp. 9375–9389, Dec. 2017.
[4] T. Kiyatmoko, “Retinal Vessel Extraction using Dynamic Threshold and Enhancement Image Filter from Retina Fundus,” Journal of InformationSystems & Telecommunication, vol. 6, no. 24, pp. 189-196, Jun. 2019.
[5] K. A. Kumar, and R. Boda, “A Threshold-based Brain Tumour Segmentation from MR Images using Multi-Objective Particle Swarm Optimization,” Journalof Information Systems and Telecommunication, vol. 9, no. 36, pp. 218-225, Oct. 2021.
[6] M. Jena, S. P. Mishra, and D. Mishra, “A survey on applications of machine learning techniques for medical image segmentation,” International Journal of Engineering & Technology, vol. 7, no. 4, pp. 4489–4495, Nov. 2018.
[7] S. Niyas, S. J. Pawan, M. Anand Kumar, and J. Rajan, “Medical image segmentation with 3D convolutional neural networks: A survey,” Neurocomputing, vol. 493, pp. 397–413, Jul. 2022.
[8] P. Dutta, P. Upadhyay, M. De, and R. G. Khalkar, “Medical image analysis using deep convolutional neural networks: CNN architectures and transfer learning,” in 2020 International Conference on Inventive Computation Technologies (ICICT), Feb. 2020, pp. 175-180.
[9] M. Jogin, Mohana, M. S. Madhulika, G. D. Divya, R. K. Meghana, and S. Apoorva, “Feature Extraction using Convolution Neural Networks (CNN) and Deep Learning,” in 2018 3rd IEEE International Conference on Recent Trends in Electronics, Information & Communication Technology (RTEICT), May 2018, pp. 2319–2323.
[10] E. Gholam, and S. R. KamelTabbakh, “Diagnosis of Gastric Cancer via Classification of the Tongue Images using Deep Convolutional Networks,” Journal of Information Systems and Telecommunication, vol. 9, no. 35, pp.191-196, Jul. 2021.
[11] I. J. Goodfellow, J. Shlens, and C. Szegedy, “Explaining and harnessing adversarial examples,” arXiv [stat.ML], 2014.
[12] Z. Hu, J. Tang, Z. Wang, K. Zhang, L. Zhang, and Q. Sun, “Deep learning for image-based cancer detection and diagnosis − A survey,”Pattern Recognition, vol. 83, pp. 134–149, Nov. 2018.
[13] X. Liu, L. Song, S. Liu, and Y. Zhang, “A Review of Deep-Learning-Based Medical Image Segmentation Methods,” Sustainability, vol. 13, no. 3, p. 1224, Jan. 2021.
[14] H. C. Shin, H.R. Roth, M. Gao, L. Lu, Z. Xu, I. Nogues, J. Yao, D. Mollura, and R.M. Summers, “Deep Convolutional Neural Networks for Computer-Aided Detection: CNN Architectures, Dataset Characteristics and Transfer Learning,” IEEE Transactions on Medical Imaging, vol. 35, no. 5, pp. 1285–1298, May 2016.
[15] S. Kazeminia, C. Baur, A. Kuijper, B. Van Ginneken, N. Navab, S. Albarqouni, and A. Mukhopadhyay, “GANs for medical image analysis,” Artificial Intelligence in Medicine, vol. 109, p. 101938, Sep. 2020. [16] Y. Fu, Y. Lei, T. Wang, W. J. Curran, T. Liu, and X. Yang, “A review of deep learning based methods for medical image multi-organ segmentation,” PhysicaMedica, vol. 85, pp. 107–122, May 2021. [17] B. Halalli, and A. Makandar, “Computer Aided Diagnosis - Medical Image Analysis Techniques,” Breast Imaging, Dec. 2017.
[18] L. Chandrashekar, and A. Sreedevi, “A two-stage multi-objective enhancement for fused magnetic resonance image and computed tomography brain images, ”Journal of InformationSystems & Telecommunication, vol. 8, no. 30, pp. 93-104, Aug. 2020.
[19] S. Zakariapour, H. Jazayeriy, and M. Ezoji, “Mitosis detection in breast cancer histological images based on texture features using adaboost, ”Journal of InformationSystems & Telecommunication, vol. 5, no. 8, pp. 1-10, Jul. 2017.
[20] M. Kumar, S. K. Khatri, and M. Mohammadian, “Breast Cancer Classification Approaches-A Comparative Analysis,” Journal of InformationSystems & Telecommunication, vol. 11, no. 41, pp. 1-11, Jan. 2023.
[21] M. M. Badža, and M. Č. Barjaktarović, “Classification of Brain Tumors from MRI Images Using a Convolutional Neural Network,” Applied Sciences, vol. 10, no. 6, p. 1999, Mar. 2020.
[22] V. Rachapudi, and G. Lavanya Devi, “Improved convolutional neural network based histopathological image classification,” Evolutionary Intelligence, vol. 14, no. 3, pp. 1337-1343, Feb. 2020.
[23] E. Shelhamer, J. Long, and T. Darrell, “Fully Convolutional Networks for Semantic Segmentation,” IEEE transactions on pattern analysis and machine intelligence, vol. 39, no. 4, pp. 640–651, Jan. 2017.
[24] J. Sun, Y. Peng, Y. Guo, and D. Li, “Segmentation of the multimodal brain tumor image used the multi-pathway architecture method based on 3D FCN,” Neurocomputing, vol. 423, pp. 34- 45, Jan. 2021.
[25] O. Ronneberger, P. Fischer, and T. Brox, “U-Net: Convolutional Networks for Biomedical Image Segmentation,” Lecture Notes in Computer Science, pp. 234–241, Oct. 2015.
[26] N. V. Dharwadkar, and A. K. Savvashe, “Right Ventricle Segmentation of Magnetic Resonance Image Using the Modified Convolutional Neural Network,” Arabian Journal for Science and Engineering, vol. 46, no. 4, pp. 3713–3722, Jan. 2021.
[27] C. Li, X. Song, H. Zhao, L. Feng, T. Hu, Y. Zhang, J. Jiang, J. Wang, J. Xiang, and Y. Sun, “An 8-layer residual U-Net with deep supervision for segmentation of the left ventricle in cardiac CT angiography,” Computer Methods and Programs in Biomedicine,vol. 200, p. 105876, Mar. 2021.
[28] Z. Zhou, M. M. RahmanSiddiquee, N. Tajbakhsh, and J. Liang, “Unet++: A nested u-net architecture for medical image segmentation,”inDeep learning in medical image analysis and multimodal learning for clinical decision support, Cham: Springer, Sep. 2018, pp. 3-11.
[29] C. Li, Y. Tan, W. Chen, X. Luo, Y. Gao, X. Jia, and Z. Wang, “Attention unet++: A nested attention-aware U-net for liver CT image segmentation,” in 2020 IEEE International Conference on Image Processing (ICIP), Oct. 2020, pp. 345-349.
[30] Milletari, N. Navab, and S. A. Ahmadi, “V-net: Fully convolutional neural networks for volumetric medical image segmentation,” in 2016 Fourth International Conference on 3D Vision (3DV),Oct. 2016, pp. 565-571.
[31] X. Guan, G. Yang, J. Yang, X. Xu, W. Jiang, and X. Lai, “3D AGSE-VNet: an automatic brain tumor MRI data segmentation framework,” BMC Medical Imaging, vol. 22, no. 1, Jan. 2022.
[32] K. He, G. Gkioxari, P. Dollar, and R. Girshick, “Mask R-CNN,” IEEE Transactions on Pattern Analysis andMachine Intelligence, vol. 42, no. 2, pp. 386–397, Mar. 2017.
[33] R. O. Dogan, H. Dogan, C. Bayrak, and T. Kayikcioglu, “A Two-Phase Approach using Mask R-CNN and 3D U-Net for High-Accuracy Automatic Segmentation of Pancreas in CT Imaging,” Computer Methods and Programs in Biomedicine, vol. 207, p. 106141, Aug. 2021.
[34] R. Yamashita, M. Nishio, R. K. G. Do, and K. Togashi, “Convolutional neural networks: an overview and application in radiology,” Insights into Imaging, vol. 9, no. 4, pp. 611–629, Jun. 2018.
[35] Y. Lecun, L. Bottou, Y. Bengio, and P. Haffner, “Gradient-based learning applied to document recognition,” Proceedings of the IEEE, vol. 86, no. 11, pp. 2278–2324, Nov. 1998.
[36] A. Krizhevsky, I. Sutskever, and G. E. Hinton, “ImageNet classification with deep convolutional neural networks,” Communications of the ACM,vol. 60, no. 6, pp. 84–90, May 2017.
[37] K. Simonyan, and A. Zisserman, “Very deep convolutional networks for large-scale image recognition,” arXiv [cs.CV], 2014.
[38] C. Szegedy, Y. Jia, P. Sermanet, S. Reed, D. Anguelov, D. Erhan, V. Vanhoucke, and A. Rabinovich “Going deeper with convolutions,” in 2015 IEEE Conference on Computer Vision and Pattern Recognition (CVPR), 2015.
[39] K. He, X. Zhang, S. Ren, and J. Sun, “Deep Residual Learning for Image Recognition,” in 2016 IEEE Conference on Computer Vision and Pattern Recognition (CVPR), 2016, pp. 770–778.
[40] R. A. Hazarika, A. Abraham, D. Kandar, and A. K. Maji, “An Improved LeNet-Deep Neural Network Model for Alzheimer’s Disease Classification Using Brain Magnetic Resonance Images,” IEEE Access, vol. 9, pp. 161194–161207, Nov. 2021.
[41] K. M. Hosny, M. A. Kassem, and M. M. Fouad, “Classification of Skin Lesions into Seven Classes Using Transfer Learning with AlexNet,” Journal of Digital Imaging, vol. 33, no. 5, pp. 1325–1334, Jun. 2020. [42] Eva-H. Dulf, M. Bledea, T. Mocan, and L. Mocan, “Automatic Detection of Colorectal Polyps Using Transfer Learning,” Sensors, vol. 21, no. 17, p. 5704, Aug. 2021.
[43] C. Szegedy, V. Vanhoucke, S. Ioffe, J. Shlens, and Z. Wojna, “Rethinking the Inception Architecture for Computer Vision,” in 2016 IEEE Conference on Computer Vision and Pattern Recognition (CVPR), Jun. 2016, pp. 2818-2826.
[44] Z. Hameed, S. Zahia, B. Garcia-Zapirain, J. Javier Aguirre, and A. MaríaVanegas, “Breast Cancer Histopathology Image Classification Using an Ensemble of Deep Learning Models,” Sensors, vol. 20, no. 16, p. 4373, Aug. 2020.
[45] M. Toğaçar, Z. Cömert, and B. Ergen, “Classification of brain MRI using hyper column technique with convolutional neural network and feature selection method,” Expert Systems with Applications, vol. 149, p. 113274, Jul. 2020.
[46] M. M. Eid, and Y. H. Elawady, “Efficient Pneumonia Detection for Chest Radiography Using ResNet-Based SVM,” European Journal of Electrical Engineering and Computer Science, vol. 5, no. 1, pp. 1–8, Jan. 2021.
[47] Xiao, B. Liu, L. Geng, F. Zhang, and Y. Liu, “Segmentation of Lung Nodules Using Improved 3D-UNet Neural Network,” Symmetry, vol. 12, no. 11, p. 1787, Oct. 2020.
[48] M. Goyal, J. Guo, L. Hinojosa, K. Hulsey, and I. Pedrosa, “Automated kidney segmentation by mask R-CNN in T2-weighted magnetic resonance imaging,” in Medical Imaging2022: Computer-Aided Diagnosis, vol. 12033, pp. 89-94, Apr. 2022.
[49] I. Goodfellow, J. Pouget-Abadie, M. Mirza, B. Xu, D. Warde-Farley, S. Ozair, A. Courville, and Y. Bengio,“Generative adversarial networks,” Communications of the ACM, vol. 63, no. 11, pp. 139–144, Oct. 2020.
[50] M. D. Cirillo, D. Abramian, and A. Eklund, “Vox2Vox: 3D-GAN for Brain Tumour Segmentation,” Brainlesion: Glioma, Multiple Sclerosis, Stroke and Traumatic Brain Injuries, pp. 274–284, Oct. 2021.
[51] W. Wang, G. Wang, X. Wu, X. Ding, X. cao, L. Wang, J. Zhang, and P. Wang “Automatic segmentation of prostate magnetic resonance imaging using generative adversarial networks,” Clinical Imaging, vol. 70, pp. 1–9, Feb. 2021.
[52] X. Wei, X. Chen, C. Lai, Y. Zhu, H. Yang, and Y. Du, “Automatic Liver Segmentation in CT Images with Enhanced GAN and Mask Region-Based CNN Architectures,” BioMed Research International, vol. 2021, pp. 1–11, Dec. 2021.
[53] J. Ma, Y. Deng, Z. Ma, K. Mao, and Y. Chen, “A Liver Segmentation Method Based on the Fusion of VNet and WGAN,” Computational and Mathematical Methods in Medicine, vol. 2021, pp. 1–12, Oct. 2021. [54] M. Arjovsky, S. Chintala, and L. Bottou, “Wasserstein Generative Adversarial Networks,” in International Conference on Machine Learning, Jul. 2017, pp. 214-223.
[55] J. Zhang, L. Yu, D. Chen, W. Pan, C. Shi, Y. Niu, X. Yao, X. Xu, and Y. Cheng, “Dense GAN and multi-layer attention based lesion segmentation method for COVID-19 CT images,” Biomedical Signal Processing and Control, vol. 69, p. 102901, Aug. 2021.
[56] A. Antoniou, A. Storkey, and H. Edwards, “Data augmentation Generative Adversarial Networks,” arXiv [stat.ML], Nov. 2017.
[57] B. Beynek, Ş. Bora, V. Evren, and A. Ugur, “Synthetic Skin Cancer Image Data Generation Using Generative Adversarial Neural Network,” International Journal of Multidisciplinary Studies and Innovative Technologies, vol. 5, no. 2, pp. 147–150, Nov. 2021.
[58] B. Ahmad, S. Jun, V. Palade, Q. You, L. Mao, and M. Zhongjie, “Improving Skin Cancer Classification Using Heavy-Tailed Student T-Distribution in Generative Adversarial Networks (TED-GAN),” Diagnostics, vol. 11, no. 11, p. 2147, Nov. 2021.
[59] V. K. Waghmare, and M. H. Kolekar, “Brain Tumor Classification Using Deep Learning,” in Internet of Things for Healthcare Technologies, Jun. 2020, pp. 155–175.
[60] A. Çinar, and M. Yildirim, “Detection of tumors on brain MRI images using the hybrid convolutional neural network architecture,” Medical Hypotheses, vol. 139, p. 109684, Jun. 2020.
[61] S. Chen, J. Zhang, X. Wei, and Q. Zhang, “Alzheimer’s Disease Classification Using Structural MRI Based on Convolutional Neural Networks,” in 2020 2ndInternational Conference on Big-data Service and Intelligent Computation, Dec. 2020, pp.7-13.
[62] V. Chouha, S.K. Singh, A. Khamparia, D. Gupta, P. Tiwari, C. Moreira, R. Damaševičius, and V.H.C. De Albuquerque, “A Novel Transfer Learning Based Approach for Pneumonia Detection in Chest X-ray Images,” Applied Sciences, vol. 10, no. 2, p. 559, Jan. 2020.
[63] C.J. Lin, and Y.C. Li, “Lung Nodule Classification Using Taguchi-Based Convolutional Neural Networks for Computer Tomography Images,” Electronics,vol. 9, no. 7, p. 1066, Jun. 2020.
[64] A. S. Abdel Rahman, S. B. Belhaouari, A. Bouzerdoum, H. Baali, T. Alam, and A. M. Eldaraa, “Breast Mass Tumor Classification using Deep Learning,” in 2020 IEEE International Conference on Informatics, IoT, and Enabling Technologies (ICIoT), Feb. 2020, pp. 271-276.
[65] Q. A. Al-Haija, and A. Adebanjo, “Breast Cancer Diagnosis in Histopathological Images Using ResNet-50 Convolutional Neural Network,” in 2020 IEEE International IOT, Electronics and Mechatronics Conference (IEMTRONICS),Sep. 2020, pp. 1-7.
[66] A. Saber, M. Sakr, O. M. Abo-Seida, A. Keshk, and H. Chen, “A Novel Deep-Learning Model for Automatic Detection and Classification of Breast Cancer Using the Transfer-Learning Technique,” IEEE Access, vol. 9, pp. 71194–71209, May 2021.
[67] K. Thurnhofer-Hemsi, and E. Domínguez, “A Convolutional Neural Network Framework for Accurate Skin Cancer Detection,” Neural Processing Letters, vol. 53, no. 5, pp. 3073-3093, Oct. 2020.
[68] K. M. Hosny, M. A. Kassem, and M. M. Foaud, “Skin melanoma classification using ROI and data augmentation with deep convolutional neural networks,” Multimedia Tools and Applications, vol. 9, no. 33, pp. 24029-24055, Jun. 2020.
[69] A. B. Bakht, S. Javed, R. Dina, H. Almarzouqi, A. Khandoker, and N. Werghi, “Thyroid Nodule Cell Classification in Cytology Images Using Transfer Learning Approach,” in International Conference on Soft Computing and Pattern Recognition, Dec. 2021, pp. 539–549.
[70] W. Chen, Z. Gu, Z. Liu, Y. Fu, Z. Ye, X. Zhang, and L. Xiao, “A New Classification Method in Ultrasound Images of Benign and Malignant Thyroid Nodules Based on Transfer Learning and Deep Convolutional Neural Network,” Complexity, vol. 2021, pp. 1–9, Sep. 2021.
[71] Eva-H. Dulf, M. Bledea, T. Mocan, and L. Mocan, “Automatic Detection of Colorectal Polyps Using Transfer Learning,” Sensors, vol. 21, no. 17, p. 5704, Aug. 2021.
[72] Y. Bhanothu, A. Kamalakannan, and G. Rajamanickam, “Detection and Classification of Brain Tumor in MRI Images using Deep Convolutional Network,” in 2020 6th International Conference on Advanced Computing and Communication Systems, Mar. 2020, pp. 248-252.
[73] W. M. Salama, and M. H. Aly, “Deep learning in mammography images segmentation and classification: Automated CNN approach,” Alexandria Engineering Journal, vol. 60, no. 5, pp. 4701–4709, Oct. 2021.
[74] A. Khouani, M. El HabibDaho, S. A. Mahmoudi, M. A. Chikh, and B. Benzineb, “Automated recognition of white blood cells using deep learning,” Biomedical Engineering Letters, vol. 10, no. 3, pp. 359–367, Jul. 2020.
[75] H. Yu, and X. Zhang, “Synthesis of Prostate MR Images for Classification Using Capsule Network-Based GAN Model,” Sensors, vol. 20, no. 20, p. 5736, Oct. 2020.
[76] S. Kaur, H. Aggarwal, and R. Rani, “Diagnosis of Parkinson’s disease using deep CNN with transfer learning and data augmentation,” Multimedia Tools and Applications, vol. 80, no. 7, pp.10113-10139,Nov. 2020.
[77] B. Mondal, N. Das, K. C. Santosh, and M. Nasipuri, “Improved Skin Disease Classification Using Generative Adversarial Network,” in 2020 IEEE 33rd International Symposium on Computer-Based Medical Systems (CBMS),Jul. 2020, pp. 520-525.
[78] T. Pang, J. H. D. Wong, W. L. Ng, and C. S. Chan, “Semi-supervised GAN-based Radiomics Model for Data Augmentation in Breast Ultrasound Mass Classification,” Computer Methods and Programs in Biomedicine, vol. 203, p. 106018, May 2021.
[79] B. Ahmad, J. Sun, Q. You, V. Palade, and Z. Mao, “Brain Tumor Classification Using a Combination of VariationalAutoencoders and Generative Adversarial Networks,” Biomedicines, vol. 10, no. 2, p. 223, Jan. 2022.
[80] Y. Li, Y. Chen, and Y. Shi, “Brain Tumor Segmentation Using 3D Generative Adversarial Networks,” International Journal of Pattern Recognition and Artificial Intelligence, vol. 35, no. 4, p.2157002,Aug. 2020. [81] A. Negi, A. N. J. Raj, R. Nersisson, Z. Zhuang, andM. Murugappan, “RDA-UNET-WGAN: An Accurate Breast Ultrasound Lesion Segmentation Using Wasserstein Generative Adversarial Networks,” Arabian Journal for Science and Engineering, vol. 45, no. 8, pp. 6399–6410, Apr. 2020.
[82] C. Decourt, and L. Duong, “Semi-supervised generative adversarial networks for the segmentation of the left ventricle in pediatric MRI,” Computers in Biology and Medicine, vol. 123, p. 103884, Aug. 2020.
[83] Z. Lou, W. Huo, K. Le, and X. Tian, “Whole Heart Auto Segmentation of Cardiac CT Images Using U-Net Based GAN,” in 2020 13th International Congress on Image and Signal Processing, BioMedical Engineering and Informatics (CISP-BMEI), Oct. 2020, pp. 192-196.
[84] X. Wu, L. Bi, M. Fulham, and J. Kim, “Unsupervised Positron Emission Tomography Tumor Segmentation via GAN based Adversarial Auto-Encoder,” in 2020 16th International Conference on Control, Automation, Robotics and Vision (ICARCV), Dec. 2020, pp. 448-453.
[85] L. Wang, Z. Q. Lin, and A. Wong, “COVID-Net: a tailored deep convolutional neural network design for detection of COVID-19 cases from chest X-ray images,” Scientific Reports, vol. 10, no. 1, pp. 1-12, Nov. 2020.
[86] E. Luz, P. Silva, R. Silva, L. Silva, J. Guimarães, G. Miozzo, G. Moreira, and D. Menotti, “Towards an effective and efficient deep learning model for COVID-19 patterns detection in X-ray images,” Research on Biomedical Engineering, Apr. 2021, pp. 1-14.
[87] N. S. Punn, and S. Agarwal, “Automated diagnosis of COVID-19 with limited posteroanterior chest X-ray images using fine-tuned deep neural networks,” Applied Intelligence, vol. 51, no. 5, pp. 2689-202, Oct. 2020.
[88] A. Waheed, M. Goyal, D. Gupta, A. Khanna, F. Al-Turjman, and P. R. Pinheiro, “CovidGAN: DataAugmentation using Auxiliary Classifier GAN for Improved Covid-19 Detection,” IEEE Access, vol. 8, pp. 91916-91923, May 2020.
[89] Y. Oh, S. Park, and J. C. Ye, “Deep Learning COVID-19 Features on CXR using Limited Training Data Sets,” IEEE Transactions on Medical Imaging, vol. 39, no. 8, pp. 2688-2700, May 2020.
[90] N. Wang, H. Liu, and C. Xu, “Deep learning for the detection of COVID-19 using transfer learning and model integration,” in 2020 IEEE 10th International Conference on Electronics Information and Emergency Communication (ICEIEC), Jul. 2020, pp. 281-284.
[91] J. Li, D. Zhang, Q. Liu, R. Bu, and Q. Wei, “COVID-GATNet: A deep learning framework for screening of COVID-19 from chest X-ray images,” in 2020 IEEE 6th International Conference on Computer and Communications (ICCC), Dec. 2020, pp. 1897-1902.
[92] M. Ahsan, M. Based, J. Haider, and M. Kowalski, “COVID-19 detection from chest X-ray images using feature fusion and deep learning,” Sensors, vol. 21, no. 4, p.1480, Jan. 2021. [93] A. S. Al-Waisy, S. Al-FahdawiS, M. A. Mohammed, K. H. Abdulkareem, S. A. Mostafa, M. S. Maashi, M. Arif, and B. Garcia-Zapirain, “COVID-CheXNet: hybrid deep learning framework for identifying COVID-19 virus in chest X-rays images,” Soft Computing,Nov. 2020, pp. 1-16.
[94] X. Li, W. Tan, P. Liu, Q. Zhou, and J. Yang, “Classification of COVID-19 Chest CT Images Based on Ensemble Deep Learning,” Journal of Healthcare Engineering, vol. 2021, pp. 1–7, Apr. 2021.
[95] Y. Pathak, P. K. Shukla, and K. V. Arya, “Deep Bidirectional Classification Model for COVID-19 Disease Infected Patients,” IEEE/ACM Transactions on Computational Biology and Bioinformatics, vol. 18, no. 4, pp. 1234–1241, Jul. 2021.
[96] M. J. Horry, S.Chakraborty, M. Paul, A. Ulhaq, B. Pradhan, M. Saha, and N. Shukla, “COVID-19 Detection Through Transfer Learning Using Multimodal Imaging Data,” IEEE Access, vol. 8, pp. 149808–149824, Aug. 2020.
[97] V. I. Iglovikov, A. Rakhlin, A. A. Kalinin, and A. A. Shvets, “Paediatric bone age assessment using deep convolutional neural networks,” in Deep Learning in Medical Image Analysis and Multimodal Learning for Clinical Decision Support, Cham: Springer International Publishing, Sep. 2018, pp. 300-308.
[98] X. Pan, Y. Zhao, H. Chen, D. Wei, C. Zhao, and Z. Wei, “Fully Automated Bone Age Assessment on Large-Scale Hand X-Ray Dataset,” International Journal of Biomedical Imaging,vol. 2020, pp. 1–12, Mar. 2020.
[99] M. A. Zulkifley, S.R. Abdani, and N.H. Zulkifley, “Automated Bone Age Assessment with Image Registration Using Hand X-ray Images,” Applied Sciences, vol. 10, no. 20, p. 7233, Oct. 2020.
[100] Y.Gao, T. Zhu, and X. Xu, “Bone age assessment based on deep convolution neural network incorporated with segmentation,” International Journal of Computer Assisted Radiology and Surgery, vol. 15, no. 12, pp.1951-1962, Sep. 2020.
[101] S. Li, B. Liu, S. Li, X. Zhu, Y. Yan, and D. Zhang, “A deep learning-based computer-aided diagnosis method of X-ray images for bone age assessment,” Complex & Intelligent Systems, pp.1-11, Apr. 2021.
[102] I. Salim, and A. B. Hamza, “Ridge regression neural network for pediatric bone age assessment,” Multimedia Tools and Applications, vol. 80, no. 20, pp. 30461–30478, May 2021.
[103] S. S. Halabi, L. M. Prevedello, J. Kalpathy-Cramer, A.B. Mamonov, A. Bilbily, M. Cicero, I. Pan, L. A. Pereira, R. T. Sousa, N. Abdala, and F.C. Kitamura, “The RSNA Pediatric Bone Age Machine Learning Challenge,” Radiology, vol. 290, no. 2, pp.498-503, Feb. 2019.
[104] L.C. Chen, G. Papandreou, I. Kokkinos, K. Murphy, and A. L. Yuille, “DeepLab: Semantic Image Segmentation with Deep Convolutional Nets, Atrous Convolution, and Fully Connected CRFs,” IEEE Transactions on Pattern Analysis and Machine Intelligence, vol. 40, no. 4, pp. 834–848, Apr. 2018.
[105] AlexSWong, “AlexSWong/COVID-Net,” GitHub,Feb. 2022, https://github.com/AlexSWong/COVID-Net.
[106] “RSNA Bone Age“, www.kaggle.com. https://www.kaggle.com/datasets/kmader/rsna-bone-age.