مرکز منطقه ای اطلاع رسانی علوم و فناوری Journal of Sports Physiology and Athletic Conditioning 2783-3038 6 19 2026 3 12 Review the effect of eight weeks of aerobic training with gallic acid on tumor necrosis factor alpha and nuclear transcription factor kappa B in prostate tissue of rats with prostate cancer Review the effect of eight weeks of aerobic training with gallic acid on tumor necrosis factor alpha and nuclear transcription factor kappa B in prostate tissue of rats with prostate cancer en Sayeh Toutounchi Avval Mohammad Ali Azarbayjani Department of Physical Education and Sport Sciences, CT.C., Islamic Azad University, Tehran, Iran Seyed Ali Hosseini Department of Sport Physiology, Marv.C, Islamic Azad University, Marvdasht, Iran Shahram Soheili Department of Physical Education and Sport Science, ShQ.C., Islamic Azad University, Shahr-e Qods, Iran Rouhallah Ershadi Department of Physical Education and sport science, Bu.C., Islamic Azad University, Bushehr, Iran 2025 12 14 Introduction: Increased inflammation in cancer-prone tissue can lead to faster progression and damage to that tissue. Although the role of exercise and antioxidants in cancer improvement has been reported, their interactive effect is not yet well understood. Therefore, the aim of the present study was to investigate the effect of eight weeks of aerobic training (AT) with gallic acid (GA) on tumor necrosis factor alpha (TNF-α) and nuclear transcription factor kappa B (NF-kB) levels in prostate tissue of rats with prostate cancer (PC). Methods: 40 male rats (age 10- 12 months and weight 260- 300 g) with prostate cancer (with the LNCaP cell line) were randomly assigned to the following groups: 1) cancer control (PCa), 2) sham (solvent of GA/(Sh)), 3) GA, 4) AT, and 5) AT+GA. Also, to investigate the effect of PC induction on the research variables, 8 healthy rats were assigned to the healthy control (HC) group. The AT groups ran three sessions per week at an intensity of 15 m/min on a 15 degree incline for 30-60 minutes for eight weeks. The GA groups also consumed daily 20 mg/kg GA orally. Results: The results showed that in the AT, GA and AT+GA groups, the levels of TNF-α and NF-kB were significantly lower than PCa group. The levels of TNF-α and NF-kB in the AT group were significantly lower than GA group. Also, in the AT+GA group, they were significantly lower than AT and GA groups. Conclusion: It seems that although AT and GA alone have a reducing effect on some inflammatory markers. However, these two (AT and GA) can enhance each other's effect on reducing inflammatory markers in prostate tissue following PC.

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