مرکز منطقه ای اطلاع رسانی علوم و فناوری Journal of Sports Physiology and Athletic Conditioning 2783-3038 5 18 2026 1 25 The Effect of Panouol Herbal Supplement Consumption on RBM24 Gene Expression in a Mouse Model of Parkinson’s Disease Following Aquatic Exercise The Effect of Panouol Herbal Supplement Consumption on RBM24 Gene Expression in a Mouse Model of Parkinson’s Disease Following Aquatic Exercise en Zahra Amrollah Islamic Azad University, Isfahan, Iran khosro Jalali Dehkordi Shahin Riyahi Malayeri Azad University, Isfahan, Iran Farzaneh Taghian Islamic Azad University 2025 10 21 <p><strong>Background:</strong> RBM24 is an RNA-binding protein involved in neuronal differentiation, RNA stability, and adult neurogenesis. Dysregulation of RBM24 has been associated with impaired neural regeneration and enhanced neurodegenerative processes, which are key pathological features of Parkinson’s disease. Considering the neuroprotective effects of exercise and herbal antioxidants, this study aimed to investigate the combined effects of aquatic exercise and Panoeol herbal supplementation on RBM24 gene expression in a mouse model of Parkinson’s disease.</p> <table> <tbody> <tr> <td width="550"> <p> </p> </td> </tr> </tbody> </table> <p><strong>Materials and Methods</strong>:Thirty male mice were randomly assigned to five groups: healthy control, Parkinson’s, Parkinson’s + aquatic exercise, Parkinson’s + Panoeol supplementation, and Parkinson’s + aquatic exercise combined with Panoeol supplementation. The aquatic exercise protocol was performed for six weeks, and Panoeol supplementation was administered daily. At the end of the intervention, brain tissue was collected, and RBM24 gene expression was quantified using real-time PCR.</p> <p><strong>Results:</strong>Parkinson’s induction significantly decreased RBM24 gene expression compared to the healthy control group. Both aquatic exercise and Panoeol supplementation independently increased RBM24 expression; however, the greatest increase was observed in the combined intervention group (p < 0.05).</p> <p><strong>Conclusion:</strong>The combination of aquatic exercise and Panoeol supplementation effectively increases RBM24 gene expression in a Parkinson’s disease mouse model. These findings suggest that RBM24 may play a key mechanistic role in the neuroprotective effects of exercise and herbal supplementation and could serve as a potential therapeutic target for slowing neurodegeneration in Parkinson’s disease.</p>

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