مرکز منطقه ای اطلاع رسانی علوم و فناوری Journal of Sports Physiology and Athletic Conditioning 2783-3038 5 18 2026 1 25 Protective effect of regular physical activity on prostate cancer complications Protective effect of regular physical activity on prostate cancer complications en Fatemeh Jamshidirad Hassan Matin Homaee Mohammad Ali Azarbayjani 2025 10 3 Prostate cancer (PCa) is one of the leading causes of cancer-related mortality and morbidity among men worldwide. Although the number of deaths from this cancer has decreased over the past decade, the incidence of PCa continues to rise globally. In addition to non-modifiable risk factors, modifiable risk factors such as diet, tobacco and alcohol consumption, obesity, and physical inactivity play a significant role in the development of PCa. Daily physical activity is an important factor in PCa risk, and incorporating it into the daily routine of healthy individua ls can substantially reduce the likelihood of developing PCa, while in affected individuals, it can significantly slow disease progression. Reviewing the results of studies investigating the effects of various exercise programs on PCa demonstrates that regular physical activity can markedly reduce the negative impacts of PCa. These changes occur both at the prostate tumor level, slowing tumor growth, and can also modulate treatment-related side effects such as quality of life (QoL), physical function capacity, muscle mass, sexual function, and fatigue. Regular physical activity exerts its protective effects in PCa patients through improving metabolic status, enhancing antioxidant defense capacity, increasing tumor growth-inhibiting myokines, and a range of other biological mechanisms. Based on the findings of this study, it is recommended that regular physical activity, particularly a combination of aerobic and resistance training, be integrated as an essential component of the management process for individu als with PCa.

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