رهایش کنترل شده موضعی دارو با استفاده از کاشتنی های پلیمری
الموضوعات :
1 - فناوری های نوین
الکلمات المفتاحية: دارورسانی موضعی, ابزارهای کاشتنی, حامل های تجزیه پذیر, حامل های تجزیه ناپذیر, رهایش هوشمند,
ملخص المقالة :
مصرف دارو به روش متداول آن اغلب حساسیت زا بوده و باعث ایجاد تراکم در بافت سالم و نیازمند مراجعه مکرر و موجب بروز مشکلات دیگر است. از این رو محققان روش های مختلفی را برای کاهش عوارض و مشکلات ارائه دادهاند. یکی از این روش ها دارورسانی موضعی با استفاده از حامل های کاشتنی در محل مورد نظر است. به طور مثال در درمان سرطان بعد از عمل جراحی به دلیل ایجاد عفونت، جلوگیری از عود تومور و داروهای دیگر، لازم است در محل جراحی رهايش داروهایی انجام شود؛ اما این رهاسازی دارو تحت عوامل مختلفی با کنترل از خارج بدن یا تغییر فاکتورهای داخل بدن انجام می شود که هرکدام به نوبه خود دارای معایب و مزایایی هستند. در رهايش کنترل شده موضعی دارو، برای ساخت حامل ها می توان از پليمرهای تجزیه پذیر و تجزیه ناپذیر متناسب با نوع بیماری و محل کاشت استفاده کرد.
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