مرکز منطقه ای اطلاع رسانی علوم و فناوری Journal of Sports Physiology and Athletic Conditioning 2783-3038 3 8 2023 4 30 The effect of eight weeks of aerobic training on some apoptotic factors of elderly men The effect of eight weeks of aerobic training on some apoptotic factors of elderly men 21 31 en Seyed Hossein Mousavi Islamic Azad University, Mahalat Bahram Abedi Islamic Azad University, Mahalat Mojtaba Khansooz Islamic Azad University 2023 1 22 Background: Considering the significant increase in apoptosis in the elderly, which is related to cardiovascular diseases, cancer, etc. The purpose of this research was to investigate the effect of eight weeks of aerobic exercise on some factors of apoptosis in elderly men was investigated. Materials and Methods: This research was conducted using a semi-experimental method with 30 healthy elderly men aged 60 to 75 years. who voluntarily participated in this research project and were randomly divided into two experimental (15 people) and control (15 people) groups. The experimental group participated in aerobic exercises for 8 weeks (three sessions of 1 hour per week) based on the special recommendations of the American College of Sports Medicine (ACSM) for the elderly. The control group did not have any physical activity during this period. Serum caspase-8, P53 and IGF-1 were measured by ELISA method. Dependent t-test and independent t-test were used to check the intra-group and inter-group differences of variables. Data analysis was done using SPSS version 20 software and the significance level was considered p≤0.05 in all steps. Results: The results showed that eight weeks of aerobic exercise increased the serum levels of caspase 8(P=0.0001) and decreased the serum levels of P53(P=0.0001) and IGF-1(insulin-like growth factor) (P=0.0001). Conclusion: According to the findings of the present research, it seems that eight weeks of aerobic exercise significantly increases the serum levels of caspase 8 and decreases the serum levels of P53 and IGF-1 in elderly men. According to these results, more research is needed in this field. http://jspac.etb.iau.ir/fa/Article/Download/40795